摘要
端粒酶被认为是恶性肿瘤诊断和治疗的新耙标 ,对端粒酶有强抑制活性的对羟基苯甲酸 4 β D 2’ ,3’ ,4’ ,6’ 四乙酰葡萄糖甙 1 D 2’ ,3’ ,4’ ,6’ 四乙酰葡萄糖酯的合成进行了研究 .通过采用丙酮法和相转移催化进行比较 ,可知相转移催化法收率更高 ,以葡萄糖计总收率可达到 2 1% .所得的产物结构经元素分析、红外光谱、核磁共振谱所证实 .
Telomerase has been found in immortalized but not in most somatic adult human tissues,and thus emerges as a novel target for cancer diagnosis and chemotherapy.This paper studies the synthesis of p hydroxy benzoic acid 4 β D 2',3',4',6' acetyl glocoside 1 D 2',3',4',6' acetyl glucoester which has great telomerase inhibiting activity.It compares the acetone method and the phase transfer method and draws a conclusion that the latter method has better yield. The total yield obtained reaches 21%from glucose. Structure of p hydroxy benzoic acid 4 β D 2',3',4',6' acetyl glocoside 1 D 2',3',4',6' acetyl glucoester are identified by elemental analysis,IR and NMR.The phase transfer method has both theoretical and pratical value.
出处
《郑州大学学报（工学版）》
CAS
2002年第3期10-12,共3页
Journal of Zhengzhou University（Engineering Science）
基金
1998年度河南省杰出青年基金资助项目
