摘要
目的探讨^(125)I放射粒子植入对Ⅱ期以内前列腺癌的临床效果。方法选取2006年3月—2015年5月绵阳市中心医院泌尿外科收治Ⅱ期以内前列腺癌62例为对象,按照治疗方法分为观察组和对照组,观察组30例,采用经直肠B超引导下经直肠植入^(125)I放射粒子。对照组32例施行前列腺癌根治手术。比较2组手术相关指标、住院天数、满意度及并发症发生率。结果观察组手术时间、术中出血量、术后住院日、输血量及住院费用均少于对照组(P <0. 05),观察组满意度高于对照组,并发症发生率低于对照组(P <0. 05)。观察组1、2、3年生存率均高于对照组(P <0. 05)。2组分别于术后出现2例前列腺特异抗原升高,给予相应治疗后好转。结论采用经直肠径路植入^(125)I粒子治疗Ⅱ期以内前列腺癌疗效满意,且具有创伤小、恢复快、对正常组织损伤低等优势。
Objective To investigate clinical effects of 125 I radioactive seed implantation in treatment of prostate cancer patients within stage II. Methods A total of 62 prostate cancer patients within stage II admitted during March 2006 and May 2015 were divided into observation group （ n =30） and control group （ n =32） according to therapeutic methods. Observation group was treated with 125 I radioactive seed implantation guided by transrectal type-B ultrasonography, while control group was treated with radical operation for prostate cancer. Operative related indexes, hospitalization expenses, satisfaction degree and incidence rate of complications were observed and compared in two groups. Results In observation group, values of operative time, intraoperative bleeding volume, postoperative hospitalization duration, volume of blood transfusion and hospitalization expenses were significantly lower （ P 〈0.05）, and satisfaction degree was better, and incidence rate of complications was significartly lower （ P 〈0.05）, and 1 year, 2-years and 3-years survival rates were significantly higher than those in control groups （ P 〈0.05）. There were 2 patients with increased prostate-specific antigen （PSA） after operation in each group, and symptoms were improved after symptomatic treatment. Conclusion 125 I radioactive seed by transrectal implantation in treatment of prostate cancer patients within stage II may achieve good with advantages such as less trauma, quick recovery and less damage to normal tissue.
作者
辛宇鹏
郭道宁
邵红刚
漆家高
周夕坪
陈正国
袁光亚
XIN Yu-peng;GUO Dao-ning;SHAO Hong-gang;QI Jia-gao;ZHOU Xi-ping;CHEN Zheng-guo;YUAN Guang-ya(a.Department of Urology Surgery,b.Department of Ultrasound,c.Department of Nuclear Medicine,1.Central Hospital of Mianyang,Mianyang,Sichuan 621000,China;Chinese Medicine Academy of Sichuan,Mianyang,Sichuan 621000,China)
出处
《解放军医药杂志》
CAS
2018年第11期40-43,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
四川省卫生厅科研课题自筹项目(070202)
关键词
前列腺肿瘤
碘放射性同位素治疗
超声
高强聚焦
经直肠
Prostatic neoplasms
Iodine Radioisotopes
Ultrasound
high-Intensity focused
transrectal
