摘要
目的:探讨脆性组氨酸三联体(fragile histidine triad,FHIT)与前列腺特异性抗原(prostate specific antigen,PSA)在前列腺癌组织中的表达及意义。方法:选取不同分级的前列腺癌组织(64例)和前列腺增生组织(32例),采用免疫组织化学SP法染色,检测FHIT及PSA的表达情况。结果:64例前列腺癌组织中病理分级(按Gleason分级系统)分化良好癌、中等分化癌和分化不良癌组织中FHIT的蛋白表达率分别为84.2%(16/19)、45.4%(10/22)和17.4%(4/23)。随着Gleason评分增加,FHIT蛋白表达率显著下降,P<0.05。病理分级中分化良好癌、中等分化癌和分化不良癌PSA的蛋白表达率分别为100%(19/19)、68.2%(15/22)和34.8%(8/23),随着Gleason评分增加,PSA蛋白表达率显著下降,P<0.05。结论:FHIT的表达与前列腺癌的Gleason评分负相关;PSA的表达与Gleason评分负相关;FHIT和PSA的表达呈正相关。
OBJECTIVE:To investigate the expression and significance of FHIT(fragile histidine triad) and PSA( prostate specific antigen) in prostatic carcinoma. METHODS: Prostatic carcinoma tissues of different pathological grades (64 cases) and prostatic hyperplasia tissues (32 cases) were selected. SP methord was used to detect the expression of FHIT and PSA. RESULTS: The expressing rates of FHIT in well differentiated, moderately differentiated and poorly differentiated tissues according to cell differentiating deg...
出处
《中华肿瘤防治杂志》
CAS
2008年第9期687-689,共3页
Chinese Journal of Cancer Prevention and Treatment
