摘要
目的:探讨白细胞(WBC)、超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)联合检测对于新生儿胎粪吸入综合征(MAS)的诊断价值。方法:选取60例胎粪吸入综合征患儿和60例正常新生儿,比较MAS患儿和正常新生儿WBC、hs-CRP及PCT含量的差异;分析MAS患儿白细胞(中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、单核细胞、淋巴细胞)检查异常的差异;单项指标检测和联合检测诊断MAS差异及灵敏度、特异度。结果:MAS患儿与正常新生儿WBC(t=13. 46,P=0. 00)、hs-CRP(t=20. 18,P=0. 00)及PCT(t=25. 90,P=0. 00)含量的差异均有统计学意义(均有P <0. 05); MAS患儿中性粒细胞、嗜酸性粒细胞、嗜碱性粒细胞、单核细胞、淋巴细胞异常率的差异有统计学意义(χ~2=27. 37,P=0. 00);单项指标WBC、PCT、hs-CRP和三项指标联合对疾病检出率的差异有统计学意义(χ~2=18. 46,P=0. 00);三项指标联合检测的灵敏度(0. 843)和特异度(0. 939)均达到最高。结论:WBC、PCT、hs-CRP对于新生儿胎粪吸入综合征的检出均有一定临床价值,三个指标的联合检测有助于疾病的明确诊断。
Objective To investigate the diagnostic value of combined detection of WBC,hs -CRP and PCT in neonatal meconium aspiration syndrome （MAS）. Method The levels of WBC, hs -CRP and PCT in MAS children and normal newborns were compared between 60 children with meeoniunl aspiration syndrome and 60 normal newborns in our hospital. The leukoeytes （ neutrophils,Eosinophils,basophils,monoeytes, and lymphoeytes）. The differences of sensitivity, specificity and specificity of single marker and combined detection were compared. Results WBC （ t = 13.46, P = 0. 00）, hs - CRP （ t = 20. 18, P = 0. 00） and PCT （t = 25.90, P = 0. 00） in MAS and normal neonates were statistically significant （P 〈 0. 05 ）. There was significant difference in the abnormal rate of neutrophils, eosinophils, basophils, monoeytes and lymphoeytes between the two groups （x^2 = 27.37, P = 0. 00）. The sensitivity, specificity and specificity of the combined detection of three indicators （WBC ,PCT, hs -CRP and three indicators） were statistically significant （x^2 = 18.46, P = 0. 00） ; the sensitivity （0. 843 ） and specificity （0. 939 ） of the three indexes were the highest. Conclusion WBC, PCT, hs - CRP have certain clinical value for the detection of neonatal meeonium aspiration syndrome, but the combined detection of 3 indicators can help to eonfirm the diagnosis of the disease.
作者
刘启星
LIU Qi-xing(Department of Pediatrics,The Second People＇s Hospital of Qingyuan（the People＇s Hospital of Qingxin District）,Qingyuan 511800,China)
出处
《吉林医学》
CAS
2018年第11期2064-2066,共3页
Jilin Medical Journal
基金
清远市科技计划项目医疗卫生领域自筹经费[项目编号:2015B078]
关键词
白细胞
超敏C反应蛋白
降钙素原
新生儿胎粪吸入综合征
Leukocyte
Hypersensitive C - reactive protein
Proealeitonin
Neonatal nmeonimn aspiration syndrome
