摘要
肝硬化是由一种或多种病因长期或反复作用形成的弥漫性肝损害。肝移植是治疗失代偿期肝硬化的有效方法,但是由于肝源紧张等因素,多数肝硬化患者因上消化道出血、肝性脑病、继发感染、癌变等并发症危及生命。干细胞治疗可以改善肝硬化,自体骨髓经门静脉移植到肝脏,更有利于干细胞在肝内的存活和增殖。对150多例失代偿期肝硬化患者做自体骨髓经门静脉移植,结果显示肝功能好转,肝脏体积增大,弹性超声检查提示肝脏硬度减低。
Cirrhosis is a diffuse liver injury caused by long-term or repeated action of one or more etiologies. Liver transplantation is an effective treatment for deeompensated cirrhosis. However, due to liver source tension and other factors, most patients with cirrhosis are at risk of life due to complications such as upper gastrointestinal bleeding, hepatic encephalopathy, secondary infection and cancer. Stem cell therapy can improve cirrhosis of the liver. Transplantation of autologous bone marrow into the liver via portal vein is more beneficial to the survival and proliferation of stem cells in the liver. More than 150 patients with deeompensated liver cirrhosis are treated by autologous bone marrow transplantation via portal vein,and the results show that the liver function is improved, the liver volume is increased, and the hardness of liver is decreased.
作者
刘保池
Liu Baochi(Department of Surgery,Shanghai Publical Health Center Affiliated to Hehai University,Shanghai 201508,China)
出处
《中华消化病与影像杂志（电子版）》
2018年第5期193-196,共4页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
基金
申康医院发展中心资助课题"自体骨髓肝内输注促进肝硬化的肝功能重建研究"(SHDC12016129)
关键词
肝硬化
干细胞
自体骨髓
肝功能
肝移植
Liver cirrhosis
Stem cells
Autologous bone marrow
Liver function
Liver transplantation
