摘要
目的探讨腹腔镜下胆囊切除术辅用消炎利胆片在治疗急性胆囊炎上的疗效、预后及血清学指标的变化情况.方法选取2017-01/2017-12在浙江省嘉兴市中医医院治疗的100例急性胆囊炎患者,随机分为观察组和对照组,各50例.对照组仅给予腹腔镜胆囊切除术,观察组在对照组基础上辅用消炎利胆片治疗,观察比较两组患者术后的临床疗效、并发症发生率、血清学指标[C反应蛋白(C reactive protein, CRP)、血清降钙素原(procalcitonin, PCT)、血清癌(cancer antigen, CA)19-9、促甲状腺激素(thyroid-stimulating hormone,TSH)、胰岛素(insulin,Ins)]的变化、术后胆总管结石复发率及肝功能指标.结果观察组的术后总有效率为90.00%,明显高于对照组的76.00%,差异有统计学意义(P <0.05);观察组术后并发症的发生率为2.00%,明显低于对照组的16.00%,差异有统计学意义(P <0.05);观察组术后1wk的血清学指标CRP、PCT、CA19-9、TSH及Ins明显低于对照组,差异有统计学意义(P<0.05);观察组术后胆总管结石的发生率为10.00%明显低于对照组的26.00%,差异有统计学意义(P<0.05);观察组患者术后的谷丙转氨酶、谷草转氨酶降低程度比对照组的明显,差异有统计学意义(P<0.05).结论腹腔镜胆囊切除术辅用消炎利胆片在治疗急性胆囊炎上,能有效改善患者机体的炎症反应,降低术后并发症发生率,提高治愈的总有效率,值得临床推广.
AIM To observe the curative effect of laparoscopic cholecystectomy combined with Xiaoyanlidan tablets in the treatment of acute cholecystitis as well as its impact on prognosis and serological indicators. METHODS One hundred cases of acute cholecystitis treated at Jiaxing Hospital of Traditional Chinese Medicine from January 2017 to December 2017 were randomly divided into an observation group and a control group, with 50 cases in each group. Both groups underwent laparoscopic cholecystectomy, and the observation group was additionally treated with Xiaoyanlidan tablets. The clinical efficacy, incidence of complications, serological indicators [C reactive protein （CRP）, procalcitonin （PCT）, cancer antigen （CA） 19-9, thyroid-stimulating hormone （TSH）, and insulin （Ins）], recurrence rate of choledocholithiasis, and indexes of liver function were observed and compared in the two groups. RESULTS The total effective rate of the observation group was 90%,which was significantly higher than that of the control group （76%, P 〈 0.05）.The incidence of postoperative complications in the observation group was 2%, which was significantly lower than that in the control group （16%, P 〈 0.05）. CRP, PCT, CA19-9, TSH, and Ins in the observation group were significantly lower than those in the control group 1 wk after operation （P 〈 0.05）. The incidence of postoperative choledocholithiasis in the observation group was 10%, which was significantly lower than that in the control group （26%, P 〈 0.05）. Glutamic-pyruvic transaminase and aspartate aminotransferase levels in the observation group were significantly lower than those in the control group （P 〈 0.05）. CONCLUSION Laparoscopic cholecystectomy combined with Xiaoyanlidan tablets can effectively improve the inflammatory response, reduce the incidence of postoperative complications, and improve the total effective rate in the treatment of acute cholecystitis.
作者
沈彬
尹浩
朱晓萍
肖卫星
周君
肖广远
周海军
Bin Shen, Hao Yin, Xiao-Ping Zhu, Wei-Xing Xiao, Jun Zhou, Guang-Yuan Xiao, Hai-Jun Zhou(Department of Hepatobiliary Surgery, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing 314000, Zhejiang Province, China)
出处
《世界华人消化杂志》
CAS
2018年第25期1523-1528,共6页
World Chinese Journal of Digestology
关键词
腹腔镜
胆囊切除术
消炎利胆片
术后疗效
血清学指标
Laparoscopy
Cholecystectomy
Xiaoyanlidan tablets
Curative effect
Serological indicators
