摘要
目的:观察滋阴清热方联合二甲双胍片治疗2型糖尿病阴虚热盛证的临床疗效。方法:将123例2型糖尿病阴虚热盛证患者随机分为观察组63例和对照组60例。对照组给予口服二甲双胍片,观察组在对照组基础上加服滋阴清热方,2组均连续用药1月。治疗后对比分析2组临床疗效,观察2组血糖、胰岛素及血脂相关指标的改善情况。结果:观察组总有效率95.24%,对照组总有效率83.33%,2组比较,差异有统计学意义(P<0.05)。治疗后,观察组空腹血糖(FBG)、餐后2h血糖(P2hBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(IR)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)水平均较治疗前下降(P<0.05),甘油三酯(TG)及高密度脂蛋白胆固醇(HDL-C)水平与治疗前比较,差异均无统计学意义(P>0.05);对照组FBG、P2hBG、HbA1c、FINS、IR水平均较治疗前下降(P<0.05);TC、TG、HDL-C及LDL-C水平与治疗前比较,差异均无统计学意义(P>0.05)。治疗后2组FBG、P2hBG、HbA1c、FINS、IR及TC水平比较,差异均有统计学意义(P<0.05),TG、HDL-C及LDL-C水平比较,差异均无统计学意义(P>0.05)。结论:滋阴清热方联合二甲双胍片治疗2型糖尿病阴虚热盛证,对患者血糖、血脂指标及胰岛素抵抗的改善效果均优于单纯二甲双胍片。
Objective： To observe the clinical effect of Ziyin Qingre prescription combined with metformin tablets for type 2 diabetes mellitus with yin deficiency and excessive heat syndrome. Methods：Divided 123 cases of patients with type 2 diabetes mellitus with yin deficiency and excessive heat syndrome into the observation group and the control group randomly,63 cases and 60 cases in each group respectively. The control group received oral administration of metformin tablets for treatment, while the observation groupwas additionally given Ziyin Qingre prescription. The two groups continuously received treatment for three months. After treatment,compared and analyzed the clinical effect in the two groups,and observed the improvement ofrelevant indexes including blood glucose,insulin and serum lipids. Results：The total curative rate was 95.24% in the observation group and was 83.33% in the control group,the difference being significant（P〈0.05）. After treatment,levels of fasting blood glucose（FBG）,postprandial 2 h blood glucose（P2hBG）,glycosylated hemoglobin（HbA1c）, fasting insulin（FINS）, insulin resistance index（IR）, total cholesterol（TC） and low density lipoprotein cholesterol（LDL-C） in the observation group were decreased when compared with those before treatment（P〈0.05）; no significant difference was found in the comparisons of triglyceride（TG） and high density lipoprotein cholesterol（HDL-C） before and after treatment（P〉0.05）. Levels of FBG, P2hBG, HbA1c, FINS and IR in the control group were decreased when compared with those before treatment（P〈0.05）;no significant difference was found in the comparisons of levels of TC,TG,HDL-C and LDL-C before and after treatment（P〉0.05）. After treatment, compared the levels of FBG, P2hBG, HbA1c, FINS, IR and TC in the two groups,differences were significant（P〈0.05）;no significant difference was found in the comparisons of levels of TG,HDL-C and LDL-C in the two groups（P〉0.05）. Conclusion： In the therapy of Ziyin Qingre prescription combined with metformin tablets for type 2 diabetes mellitus with yin deficiency and excessive heat syndrome,its improvement of blood glucose,serum lipidsandinsulin is better than that of the simple metformin tablets.
出处
《新中医》
CAS
2018年第9期82-84,共3页
New Chinese Medicine
关键词
2型糖尿病
阴虚热盛证
中西医结合疗法
滋阴清热方
二甲双胍片
血糖
胰岛素
血脂
Type 2 diabetes mellitus
Yin deficiency and excessive heat syndrome
Integrated Chinese and western medicine therapy
Ziyin Qingre prescription
Metformin tablets
Blood glucose
Insulin
Serum lipid
