摘要
目的探讨分子分型与乳腺癌新辅助化疗患者保乳手术(BCS)率和病理完全缓解(p CR)率的相关性。方法回顾性分析180例接受新辅助化疗(NCT)的局部晚期乳腺癌患者,分析NCT后分子分型与BCS及p CR的相关性并分析其影响因素。结果 44例(24.4%)获得p CR,Basal-like、ERBB2+的患者p CR率(38.9%、41.5%)分别高于Luminal A、Luminal B(5.0%、14.5%),差异有统计学意义(P<0.05)。多因素分析显示,分子分型、临床T分期是p CR的独立预测因子(P<0.05)。27例(15.0%)行BCS,Basal-like、ERBB2+的患者BCS率(25.0%、29.3%)分别高于Luminal A、Luminal B(4.8%、25.0%),差异有统计学意义(P<0.05)。多因素分析显示,分子分型是BCS的独立预测因子(P<0.05)。结论与Luminal A和Luminal B患者相比,ERBB2+和Basal-like患者的BCS和p CR率更高。
Objective To investigate the relationship between molecular typing and breast -conserving surgery- （BCS） rate and pathologic complete response （pCR） rate in patients with breast cancer neoadjuvant chemotherapy（NCT）. Methods The clinical and pathological data of 180 patients with locally advanced breast cancer who underwent neoadjuvant chemotherapy were retrospectively analyzed. The correlation between molecular typing and BCS and pCR after neoadjuvant chemotherapy and the influeneing factors of BCS and pCR were analyzed. Results The pCR was obtained in 44 patients （24. 4% ）. The rates of pCR in Basal -like and ERBB2 ＋ patients （38.9% and 41.5% ） were significantly higher than those in Luminal A and Luminal B （5.0% and 14. 5 % ）, the difference was statistically significant （ P 〈 0. 05 ）. Multivariate analysis showed that molecular typing and clinical T staging were independent predictors of pCR （ P 〈 0. 05）. In 27 eases （ 15.0% ） with BCS,the BCS rates （25.0%, 29. 3%） of Basal -like and ERBB2 ＋ patients were higher than those of Luminal A and Luminal B （4. 8%, 25.0%）, respectively, and the differences were statistically significant （P 〈 0. 05 ）. Multivariate analysis showed that molecular typing was an independent predictor of BCS （ P 〈 0. 05 ）. Conclusion BCS and pCR rates are higher in ERBB2 ＋ and Basal - like patients compared with Luminal A and Luminal B patients.
作者
秦威
李林
王楠
谷元廷
Qin Wei;Li Lin;Wang Nan;Gu Yuanting(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2018年第18期3286-3289,共4页
Henan Medical Research
关键词
乳腺癌
新辅助化疗
保乳手术
breast cancer
neoadjuvant chemotherapy
breast - conserving surgery-
