摘要
目的观察风湿Ⅱ号药膏穴位贴敷治疗湿热痹阻型类风湿关节炎(RA)的临床疗效,以及其对患者类风湿因子(RF)、红细胞沉降率(ESR)、C反应蛋白(CRP)水平的影响。方法将106例湿热痹阻型RA患者按照随机数字表法分为2组。对照组53例予甲氨蝶呤片治疗;治疗组53例在对照组治疗基础上加用风湿Ⅱ号药膏穴位贴敷治疗。2组均治疗3个月后统计疗效,比较2组治疗前后关节肿胀数、关节压痛数及晨僵持续时间变化情况;比较2组治疗前后生活质量改善情况,采用健康状况评定量表(HAQ)进行评定,包括穿衣和修饰、饮食、站立、卫生、行走、抓握、伸手取物及活动8项内容;比较2组治疗前后RF、ESR及CRP水平变化情况。结果治疗组总有效率88.68%,对照组总有效率71.70%,治疗组疗效优于对照组(P<0.05);2组治疗后与本组治疗前比较,关节肿胀数及关节压痛数减少(P<0.05),晨僵持续时间缩短(P<0.05),且治疗后治疗组对关节肿胀数、关节压痛数及晨僵持续时间改善均优于对照组(P<0.05);2组治疗后与本组治疗前比较,HAQ穿衣和修饰、饮食、站立、卫生、行走、抓握、伸手取物、活动各项评分及总分均明显降低(P<0.05),且治疗后治疗组对HAQ各项评分及总分改善均优于对照组(P<0.05);2组治疗后与本组治疗前比较,RF、ESR及CRP水平均明显降低(P<0.05),且治疗后治疗组RF、ESR及CRP水平均低于对照组(P<0.05)。结论风湿Ⅱ号药膏穴位贴敷治疗湿热痹阻型RA疗效确切,可明显改善患者临床及体征,提高生活质量,提高临床疗效,其作用机制可能与降低RF、ESR及CRP水平有关。
Objective To observe the effects of acupoint application of rheumatism Ⅱ ointment on rheumatoid arthritis（ RA） with damp-heat stagnation syndrome and its effect on rheumatoid factor（ RF）,erythrocyte sedimentation rate（ ESR） and c-reactive protein（ CRP） level. Methods 106 patients with damp-heat stagnation syndrome RA were divided into two groups according to the random number table method. 53 cases in control group were treated by methotrexate tablets. 53 cases in treatment group were treated by rheumatism Ⅱ ointment acupoint application on the basis of the control group. The curative effect was evaluated after 3 months of treatment in both groups.The number of joint swelling,joint tenderness and the duration of morning stiffness were compared before and after treatment. The improvement of quality of life before and after treatment was compared between the two groups. The improvement of quality of life before and after treatment in the two groups was compared and assessed by health status rating scale（ HAQ）,including dressing and modification,diet,standing,hygiene,walking,grasping,reaching for objects and activities. The changes of RF,ESR and（ CRP） levels were compared before and after treatment. Results The total effective rate was 88. 68 % in treatment group and 71. 70% in control group. The therapeutic effect of the treatment group was better than that of the control group（ P〈0. 05）. After treatment,the number of joint swelling and tenderness decreased（ P〈0. 05） and the duration of morning stiffness shortened（ P〈0. 05）,and the improvement of joint swelling,joint tenderness and morning stiffness duration in the treatment group were better than those in the control group（ P〈0. 05）. After treatment,the HAQ dressing and modification,diet,standing,hygiene,walking,grasping,reaching for objects and activities scores and total scores of the two groups were significantly lower（ P〈0. 05）,and the scores of treatment group were better than of the control group（ P〈0. 05）. After treatment,the RF,ESR and CRP levels were significantly lower in the two groups（ P〈0. 05）,and those indexes of the treatment group was lower than that of the control group（ P〈0. 05）. Conclusion The application of rheumatism Ⅱ acupoint application in the treatment of RA with damp-heat stagnation syndrome can significantly improve the clinical and physical signs of patients,improve the quality of life and improve the clinical efficacy. The mechanism may be related to the reduction of RF,ESR and CRP levels.
作者
汪洪波
杨远
宋妮
WANG Hongbo;YANG Yuan;SONG Ni(Department of Rheumatology and Immunology,Chinese Medicine Hospital,Qinhuangdao,Hebei 06600)
出处
《河北中医》
2018年第9期1306-1310,共5页
Hebei Journal of Traditional Chinese Medicine
基金
秦皇岛市科学技术局2016年市级科技计划(第二批)项目(编号:201602A118)
关键词
关节炎
类风湿
穴位贴敷法
中药疗法
辨证论治
Arthritis
rheumatoid
Acupoint application
Chinese medicine therapy
Syndrome differentiation
