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地特胰岛素联合利格列汀治疗老年2型糖尿病的临床观察 被引量:6

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摘要 目的探讨地特胰岛素联合利格列汀治疗老年2型糖尿病的临床疗效及安全性。方法 42例口服2~3种降糖药物血糖控制仍不佳的老年2型糖尿病患者,给予地特胰岛素联合利格列汀治疗。观察患者治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红白蛋白(HbA1c)、空腹C肽、餐后2 h C肽、体质量指数(BMI)水平变化情况,以及治疗后血糖控制情况,并记录低血糖等发生情况。结果本组患者治疗前后BMI、空腹C肽水平比较差异无统计学意义(P>0.05);治疗后,本组患者FPG、2 h PG、HbA1c以及餐后2 h C肽水平均较治疗前明显改善,差异具有统计学意义(P<0.05)。治疗后,血糖控制良好为23例(54.8%),血糖控制尚可为10例(23.8%),血糖控制差为9例(21.43%)。出现乏力、多汗、饥饿感明显等低血糖反应2例,检测血糖较前明显下降,但均>3.8 mmol/L,进食后好转。无严重低血糖发生,无肝肾等其他不良反应。结论地特胰岛素联合利格列汀治疗老年2型糖尿病可有效平稳降糖,低血糖发生率低,安全可靠,值得推广。
出处 《中国实用医药》 2018年第21期136-137,共2页 China Practical Medicine
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