摘要
目的分析利格列汀联合胰岛素治疗糖尿病肾病(diabetic nephropathy,DN)的应用效果。方法选取2020年8月—2022年8月哈尔滨市第一医院收治的DN患者38例,通过随机掷骰子法将其分为参照组和联合组,每组19例。参照组患者给予常规胰岛素降糖治疗;联合组给予利格列汀联合胰岛素治疗。对比两组患者治疗前后的临床指标变化情况及不良反应发生率。结果治疗前两组患者的临床指标比较,差异无统计学意义(P>0.05)。治疗后,两组患者的临床指标数据均有所改善,且联合组患者的临床指标均优于参照组,联合组患者的不良反应率(5.26%)显著低于参照组患者(36.84%),差异有统计学意义(P<0.05)。结论DN患者使用胰岛素降糖治疗期间,给予利格列汀联合给药治疗办法,可以更为有效地帮助肾脏相关指标水平恢复,从而降低对肾脏的进一步影响,减少药物使用产生的不良反应风险,从而提升整体治疗应用效果。
Objective To analyze the application effect of linagliptin combined with insulin in the treatment of diabetic nephropathy(DN).Methods Thirty-eight patients with DN admitted to Harbin First Hospital from August 2020 to August 2022 were selected,and they were divided into,reference group and combined group by random dice rolling method,with 19 cases in each group.The patients in the reference group were given conventional insulin hypoglycemic,and the combined group was given linagliptin combined with insulin.The changes of clinical indexes and the rate of adverse reactions of patients in the two groups before and after treatment were compared.Results There was no statistically significant difference in clinical indicators between the two groups of patients before treatment(P>0.05).After treatment,the clinical indicator data of both groups of patients improved,and the clinical indicators of the combination group patients were significantly better than those of the reference group patients,the adverse reaction rate of the combination group patients(5.26%)was significantly lower than that of the reference group patients(36.84%),and the difference was statistically significant(P<0.05).Conclusion During the treatment of patients with DN with insulin hypoglycemia,the administration of linagliptin in combination with the therapeutic approach can more effectively help the recovery of kidney-related index levels,thus reducing further effects on the kidneys and reducing the risk of adverse reactions arising from drug use,thus enhancing the overall therapeutic application effect.
作者
张桂红
ZHANG Guihong(Department of Nephrology,Harbin First Hospital,Harbin,Heilongjiang Province,150010 China)
出处
《糖尿病新世界》
2023年第8期81-83,90,共4页
Diabetes New World Magazine
