摘要
目的探讨老年人发生脑白质疏松的危险因素及脑白质疏松对老年人认知功能的影响。方法选取2013-10—2016-11郑州市第九人民医院43例脑白质疏松患者为研究组,另选取同期体检健康者43例为对照组。统计2组糖尿病、高血压、高血脂、饮酒、吸烟、慢性阻塞性肺疾病等基本情况,抽取所有患者空腹静脉血4mL,以血糖分析仪测定空腹血糖、血脂、纤维蛋白原等实验室指标水平。统计分析脑白质疏松发病危险因素、危险因素与脑白质疏松病情相关性及2组认知功能(MMSE、MoCA)评分。结果年龄、糖尿病、高血压及纤维蛋白原水平均是脑白质疏松发病的影响因素(P<0.05),Logistic回归分析可知,年龄、糖尿病、高血压及纤维蛋白原水平均是脑白质疏松发病的独立危险因素(P<0.05)。Spearman检验可知,脑白质疏松发病危险因素年龄、糖尿病、高血压及纤维蛋白原水平均与脑白质疏松呈明显正相关关系(P<0.05)。研究组MMSE评分(22.53±3.48)分、MoCA评分(23.01±3.50)分低于对照组[(28.04±0.89)分、(28.13±0.90)分],差异有统计学意义(P<0.05)。结论脑白质疏松可对老年患者认知功能产生一定损害,年龄、糖尿病、高血压及纤维蛋白原水平均是导致脑白质疏松发生的独立危险因素,且其与患者病情存在明显正相关关系,临床可通过对上述危险因素进行积极干预防治脑白质疏松。
Objective To investigate the risk factors of leukoaraiosis in the aged and its influence on the cognitive function.Methods From October 2013 to November 2016,43 patients with leukoaraiosis in the Ninth People＇s Hospital of Zhengzhou were selected as the study group,and another 43 healthy people in the same period were selected as the control group.The basic information of two groups such as diabetes,hypertension,hyperlipidemia,drinking,smoking,chronic obstructive pulmonary disease,etc.was statistically recorded.The fasting blood glucose,blood lipid,fibrinogen and other laboratory indexes were measured by the blood glucose analyzer in 4 ml of the fasting venous blood of all the subjects.The risk factors of leukoaraiosis and the correlation between risk factors and leukoaraiosis and the cognitive function（MMSE,MoCA）score of two groups were statistically analyzed.Results Age,diabetes,hypertension and fibrinogen level were the factors affecting the incidence of leukoaraiosis（P〈0.05）.Logistic regression analysis showed that age,diabetes,hypertension and fibrinogen level were the independent risk factors for the onset of leukoaraiosis（P〈0.05）.Spearman test showed that the risk factors for leukoaraiosis as age,diabetes,hypertension and fibrinogen were significantly positively correlated with leukoaraiosis（P〈0.05）.The MMSE score and MoCA score of the study group were（22.53±3.48）points and（23.01±3.50）points,lower than those of the control group[（28.04±0.89）points and（28.13±0.90）points],and the difference was statistically significant（P〈0.05）.Conclusion Leukoaraiosis can cause damage to the cognitive function of the elderly patients.Age,diabetes,hypertension and fibrinogen are the independent risk factors of leukoaraiosis.There is a positive correlation between the risk factors and patient＇s condition.The prevention and treatment of leukoaraiosis can be carried out by the active intervention of the above risk factors.
作者
赵玲玲
张萍
肖红
ZHAO Lingling , ZHANG Ping, XIAO Hong(Radiology Department ,the Ninth People＇s Hospital of Zhengzhou ,Zhengzhou 450000,Chin)
出处
《中国实用神经疾病杂志》
2018年第11期1238-1243,共6页
Chinese Journal of Practical Nervous Diseases
基金
2014年郑州市科技局立项的普通科技攻关项目(项目编号20140492)
