摘要
鼻咽癌是中国南方地区最常见的恶性肿瘤之一,其主要发病因素包括遗传易感性、饮食因素和EB病毒(Epstein-Barr virus,EBV)感染。鼻咽癌患者血浆中存在持续阳性的EBV DNA,其拷贝数与肿瘤的分期相关,有效治疗后迅速下降,复发和转移时再次升高。越来越多的研究显示,血浆EBV DNA检测在鼻咽癌早期诊断和筛查、肿瘤复发和转移诊断、预后判断以及个体化治疗等方面具有较大的价值。本文就以上问题进行分析总结以供临床和未来的研究参考。
Nasopharyngeal carcinoma is one of the most common malignant tumors in the southern part of China. The main etiological factors of nasopharyngeal carcinoma include genetic susceptibility, dietary factors, and Epstein-Barr virus （EBV） infection. EBV deoxyribonucleic acid （EBV DNA） can be persistently detected in the plasma of patients with nasopharyngeal carcinoma, and its levels correlate with the disease stage. After successful treatment, EBV DNA is rapidly cleared from the plasma of patients; however, significant increases in plasma EBV DNA levels are observed in patients with recurrent or metastatic diseases after treatment. Accumulating evidence suggests that EBV DNA detection is useful in the early diagnosis and screening, diagnosis of tumor recurrence or distant metastasis, prognosis, and tailored treatment of patients with nasopharyngeal carcinoma. This review summarizes the aforementioned progresses to provide a basis for future clinical and research efforts.
作者
李金高
林少俊
陈晓钟
Jingao Li;Shaojun Lin;Xiaozhong Chen(Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang 330029, China;Department of Radiation Oncology, Fujian Cancer Hospital,Fuzhou 350014, China;Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2018年第10期487-491,共5页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金项目(编号:81460409)资助~~
关键词
鼻咽癌
EB病毒DNA
诊断
筛查
nasopharyngeal carcinoma
EBV DNA
diagnosis
screening
