摘要
目的观察影像引导下微波消融联合化疗治疗非小细胞肺癌的临床疗效。方法回顾性分析住院治疗的非小细胞肺癌患者92例,根据治疗方式不同分为观察组(46例)及对照组(46例),比较两组近期疗效及并发症发生情况。结果观察组有效率为76.1%(35/46),高于对照组的47.8%(22/46),差异有统计学意义(χ~2=7.793,P<0.05)。观察组患者气胸、胸痛发生率均高于对照组,差异均有统计学意义(P<0.05),但气胸和胸痛程度均较轻,均于48 h内恢复;两组患者咯血、胸腔积液、发热、骨髓抑制、恶心呕吐、肾功能不全发生率比较,差异均无统计学意义(P>0.05)。结论影像引导下微波消融联合化疗可以提升非小细胞肺癌的治疗效果,安全性较高,是一种可靠的治疗方式,值得临床推广使用。
Objective To observe the clinical efficacy of microwave ablation combined with chemotherapy in the treatment of non-small cell lung cancer（NSCLC）. Method 92 cases of NSCLC treated in the hospital were retrospective analyzed, and were assigned as study group（n=46） or control group（n=46） according to their respective therapy, to compare the short-term clinical efficacy and the occurrence of complications. Result The response rate in the study group was 76.1%（35/46）, which was higher than that in the control group at 47.8%（22/46）, with significant difference observed（χ-2=7.793, P〈0.05）. The incidence of pneumothorax and chest pain in study group were significantly higher than those in the control group（P〈0.05）, and were mainly mild, which were resolved within 48 h; there were no significant differences regarding the incidence of hemoptysis, pleural effusion, fever, bone marrow suppression, nausea, vomiting and renal impairment between the two groups（P〉0.05）. Conclusion Image-guided microwave ablation combined with chemotherapy can improve the clinical efficacy for NSCLC, it is a safe and reliable therapy, and is worthy of clinical application.
作者
王启船
张鹏
万里新
王文廉
陶海云
王青
赵得堡
屈中玉
孙星
WANG Qichuan;ZHANG Peng;WAN Lixin;WANG Wenlian;TAO Haiyun;WANG Qing;ZHAO Debao;QU Zhongyu;SUN Xing(Department of Oncology;Department of Emergency, the First People＇s Hospital of Nantong City, Nantong 226001, Jiangsu, China;Disinfection Supply Center, Nanyang Central Hospital, Nanyang 473009, He＇ nan, China)
出处
《癌症进展》
2018年第4期439-441,共3页
Oncology Progress
关键词
微波消融
非小细胞肺癌
化疗
CT引导
疗效
microwave ablation
NSCLC
chemotherapy
CT-guided
clinical efficacy
