摘要
目的:研究基于微纳马达抗肿瘤药物的靶向运动及可控释放。方法:通过外源磁场实现阴阳微胶囊的定向运动,利用近红外激光诱导实现肿瘤药物的可控释放。结果:在相同的时间内,过氧化氢浓度为15%的水溶液中阴阳微胶囊马达的运动速度最大,最大速度为36.8μm·s^(-1),每秒运动约3个马达身长。在外源磁场的控制下,微胶囊马达沿特定轨迹进行运动,到达HeLa细胞附近区域。通过近红外激光进行照射,微胶囊发生破裂并迅速释放被包覆的药物,使HeLa细胞凋亡。结论:阴阳微胶囊马达作为药物载体可实现安全有效的靶向药物运输,在癌症的诊断治疗方面展现良好应用前景。
Objective： To investigate the targeted motion and controllable release of tumor drugs based on micromotor. Methods： The directional movement of Janus micro-capsules was achieved through an external magnetic field, and the controllable release of tumor drugs was induced by near-infrared laser. Results： During the same period, the movement speed of the Janus capsules micromotor was the fastest （36.8 μm· s-1 , approximately equalled to 3 body length · s-1 ） in 15% H2O2 solution. Under the control of the external magnetic field, the Janus capsules micromotor could move along the scheduled trajectory close to the area of HeLa cells. Through the irradiation of near-infrared laser, the Janus capsules micromotor was broken and released the loaded drugs quickly. Conclusion： The Janus capsule micromotor studied in the paper can be used for targeted drug delivery safely and effectively, therefore, it shows good application prospect in the field of tumor diagnosis and treatment.
作者
李牧
袁野
岳凤莲
郑秋艳
黄海燕
程彦文
Li Mu;Yuan Ye;Yue Fenglian;Zheng Qiuyan;Huang Haiyan;Cheng Yanwen(Department of Pharmacy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China)
出处
《中国药师》
CAS
2018年第5期779-783,共5页
China Pharmacist
基金
国家自然科学基金资助项目(编号:51705108)
黑龙江省省属高等学校基本科研业务费基础研究项目(编号:2017LCZX45)
关键词
微纳马达
微胶囊
肿瘤药物
靶向治疗
Micro-nanomotor
Micro-capsules
Tumor drug
Targeted therapy
