摘要
目的探讨血清炎症因子与胃癌证型的相关性。方法收集112例胃癌患者血清,运用免疫电化学发光技术检测10种炎症因子的表达水平,非参数检验进行相关性分析。结果血清IL-10水平在胃癌9种证型间存在显著差异(Z=16.085,P=0.041),在实证组不同中医证型IL-10的表达水平存在显著差异(P<0.05)。气阴两虚证IL-1β表达水平高于脾胃虚弱证,差异具有统计学意义(P<0.05)。结论血清IL-10水平对胃癌实证具有诊断价值,IL-1β对胃癌虚证具有诊断价值。
Objective To evaluate the correlation between serum inflammatory cytokines and syndrome differentiation of traditional Chinese medicine in patient with gastric cancer. Methods 112 hospitalized patients with gastric cancer were selected to provide serum. Detect the expression level of the 10 kinds of inflammatory factors by immuno - electrochemical luminescence technique, non parametric test for correlation analysis. Results There was a significant difference in the level of serum IL - 10 between the 9 types of syndrome differentiation（ Z = 16.085 ,P 〈 0.05 ）. In the empirical group, the expression level of IL - 10 between different TCM syndrome typeshas statistical significance（P 〈 0.05 ）. The level of ILl -β in Qi and Yin deficiency syndrome group were significantly higher than the deficiency of the spleen and stomach group,the comparison shows significant difference（ P 〈 0.05 ）. Conclusion The level of serum IL -10 is of diagnostic value in the diagnosis of Shi syndrome, and IL- 1β has a diagnostic value for Xu syndrome.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2017年第12期3043-3047,共5页
Lishizhen Medicine and Materia Medica Research
基金
国家自然科学基金(81473593
81473458)
江苏省青蓝工程(JSQL-2014)
江苏干部保健科研课题(BJ14013)
关键词
胃癌
证型
炎症因子
Gastric cancer
Syndrome differentiation
Inflammatory cytokines
