摘要
目的:对左卡尼汀注射液超说明书用药的文献以Jadad量表进行评价,评估该药在上海交通大学医学院附属瑞金医院超说明书使用的合理性。方法:检索文献,运用临床试验质量评价工具——改良Jadad量表进行评分,>4分的文献作为高质量文献。随机抽取该院使用左卡尼汀注射液的医嘱360份进行处方点评,结合文献依据,评估左卡尼汀注射液的用药合理性。结果:在用Jadad量表法筛选的文献中,左卡尼汀主要用于营养心肌、稳定心脏功能、改善心肌代谢等治疗。处方点评显示,本院左卡尼汀注射液超说明书用药现象显著,其中超适应证医嘱309份(占85.83%),临床诊断主要集中在心脏术后辅助用药和胸外科肿瘤切除术后改善用药,未发现相关药品不良反应。结论:用改良Jadad量表法筛选高质量文献,有望作为临床超说明书用药合理性评价的工具。
Objective：To evaluate the literature on off-label drug use of levocarnitine injection by the Jadad scale,so as to assess the medication rationality of levocarnitine injection in Ruijin Hospital Affiliated to School of Medicine,Shanghai Jiaotong University.Methods：All the literature on off-label drug use of levocarnitine injection were included and evaluated by the modified Jadad Scale.Literature with scores of more than 4 were selected as evidence for off-label drug use.Totally 360 prescriptions using levocarnitine injection were randomly selected to analyze the medication rationality of levocarnitine injection in this hospital.Results：Levocarnitine injection was usually used for nutrition myocardium,stablization of cardiac function,improvement of myocardial metabolism and so on in the literature selected by Jadad scale.Prescription reviews revealed that there were 309 cases of supernumerary indication drug use,accounting for 85.83%.Levocarnitine injection was mainly used as adjuvant drugs after cardiac surgery and resection of thoracic tumor,and no adverse drug reactions were reported.Conclusion：It would be a new tool that modified Jadad scale could be used for assessment of medication rationality by screening high quality literature.
出处
《药学服务与研究》
CAS
2017年第6期470-472,共3页
Pharmaceutical Care and Research
