摘要
目的探讨普瑞巴林联合依托考昔治疗膝关节骨关节炎疼痛的临床疗效。方法选取商丘市第一人民医院2014年2月—2016年2月收治的膝骨关节炎疼痛患者80例,按照随机数字表法将患者分为观察组和对照组,各40例。观察组患者予以普瑞巴林胶囊与依托考昔片治疗,对照组患者予以依托考昔片治疗,两组患者均连续治疗8周。比较两组患者治疗前、治疗1周、4周及8周膝关节视觉模拟评分量表(VAS)评分、日常活动程度量表(WOMAC)评分,治疗前后焦虑自评量表(SAS)评分、匹兹堡睡眠质量指数(PSQI)评分、肝肾功能指标[谷丙转氨酶(ALT),谷草转氨酶(AST),血肌酐(Cr)、尿素氮(BUN)],观察两组患者不良反应发生情况。结果治疗前两组患者膝关节VAS评分、WOMAC评分比较,差异无统计学意义(P>0.05);治疗1周、4周及8周观察组患者膝关节VAS评分、WOMAC评分低于对照组(P<0.05);两组患者治疗1周、4周及8周膝关节VAS评分、WOMAC评分低于治疗前(P<0.05)。治疗前两组患者SAS和PSQI评分比较,差异无统计学意义(P>0.05);治疗后观察组患者SAS和PSQI评分低于对照组(P<0.05);两组患者治疗后SAS评分低于治疗前,观察组患者治疗后PSQI评分低于治疗前(P<0.05)。治疗前后两组患者ALT、AST、Cr和BUN水平比较,差异无统计学意义(P>0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论瑞普巴林联合依托考昔治疗膝关节骨关节炎疼痛的临床疗效确切,其镇痛效果好,可有效改善患者膝关节功能、焦虑程度和睡眠质量,安全性高。
Objective To study the clinical effect of pregabalin combined with etoricoxib in the treatment of the pain of knee osteoarthritis. Methods A total of 80 cases of patients with knee osteoarthritis pain were selected from February 2014 to February 2016 in Shangqiu First People' s Hospital,which were divided into control group and observation group according to random table number method,40 cases in each group. Observation group was given pregabalin combined with etoricoxib,control group was treated with etoricoxi,both groups were treated for 8 weeks. The two groups of VAS scores and WOMAC scores before treatment and after treatment of 1,4,8 weeks and the SAS scores,PSQI scores and liver and kidney function( ALT,AST,Cr,BUN) were compared between the two groups,and the incidence of adverse reactions were observed. Results Before treatment,no statistically significant differencs of VAS scores or WOMAC score was found between the two groups( P > 0. 05);after treatment of 1,4 and 8 weeks,the VAS scores and WOMAC scores of observation group were lower than control group( P< 0. 05),the VAS scores and WOMAC scores of two groups were lower than prior treatment( P < 0. 05). Before treatment,no statistically significant differencs of SAS scores or PSQI scores was found between the two groups( P > 0. 05); after treatment,the SAS scores and PSQI scores of observation group were lower than control group( P < 0. 05); the SAS scores of two groups were lower than prior treatment,PSQI scores of observation group were lower than prior treatment( P < 0. 05). Before and after treatment,no statistically significant differencs of ALT、AST、Cr or BUN levels was found between the two groups( P > 0. 05).The incidence of adverse reactions of observation group was lower than control group( P < 0. 05). Conclusion Pregabalin combined with etoricoxib have an obviously clinical effect in the treatment of the pain of knee osteoarthritis,it has good analgesic effect,which can significantly improve the knee joint function,degree of anxiety and sleep quality,and with high safety.
出处
《中国全科医学》
CAS
北大核心
2017年第A01期33-36,共4页
Chinese General Practice
