摘要
目的探讨对胰岛素控制不佳的2型糖尿病患者行沙格列汀药物治疗的效果。方法选择我院于2014年11月~2015年10月期间所收治的2型糖尿病患者共72例,采用随机数字表法将其平均分成观察组和对照组,每组36例。两组患者行常规治疗方法控制血糖,并加用胰岛素治疗。在此基础上,观察组患者加行沙格列汀药物治疗,并依据患者的病症发展情况对胰岛素和沙格列汀剂量进行控制。对比两组患者治疗后的各项指标如体质量、空腹血糖、餐后2 h血糖、糖化血红蛋白(Hb A1c)以及胰岛素用量等指标变化情况。结果经过为期3个月的治疗后,上述观察指标对比中,观察组各项指标分别为(70.4±14.0)kg、(5.5±1.4)mmol/L、(11.0±2.0)mmol/L、(7.3±1.2)%、(25.5±12.3)IU/d;对照组分别为(78.1±17.3)kg、(8.6±1.7)mmol/L、(13.5±3.9)mmol/L、(8.9±1.5)%、(48.3±16.0)IU/d,证实观察组的好转率优于对照组。两组患者的空腹血糖值、餐后2 h血糖等指标较治疗前均明显降低,差异有统计学意义(P<0.05)。另外,两组患者均未出现低血糖事件,对照组2例出现排气增加情况,观察组为0例,证实观察组无并发症发生。结论应用沙格列汀对胰岛素控制不佳的2型糖尿病患者进行治疗的效果显著,不但能够减低胰岛素的日常用量,同时有效对胰岛素抵抗情况进行改善,沙格列汀值得临床应用和推广。
Objective To investigate the effect of saxagliptin in the treatment of type 2 diabetes mellitus with poor insulin control. Methods A total of 72 patients with type 2 diabetes mellitus who were admitted to our hospital from November2014 to October 2015 were selected. Based on the random number table method, the patients were evenly divided into observation group and control group, with 36 patients in each group. The two groups of patients were given routine treatment. The blood sugar was controlled, and insulin was added for the treatment. On this basis, the observation group was further given saxagliptin for the treatment, and the doses of insulin and saxagliptin were controlled according to the development of conditions. The changes of several indices, such as body weight, fasting blood glucose, 2-hour post-prandial blood glucose, glycosylated hemoglobin（Hb A1 c） and insulin consumption were compared between the two groups after the treatment. Results After 3 months of treatment, in the comparison of the above indices between the two groups, the indices in the observation group were（70.4±14.0） kg,（5.5±1.4） mmol/L,（11.0±2.0） mmol/L,（7.3±1.2）%, and（25.5±12.3） IU/d, respectively, and the control group were（78.1±17.3） kg,（8.6±1.7） mmol/L,（13.5±3.9） mmol/L,（8.9±1.5）%, and（48.3±16.0） IU/d respectively, demonstrating that the improvement rate in the observation group was better than the control group. The fasting blood glucose and 2-hour post-prandial blood glucose in each group were significantly lower than those before treatment, and the differences were significant（P〈0.05）. In addition, hypoglycemic events did not appear in the two groups of patients. In the control group, there were 2 cases of increased exhaust gas, but0 case in the observation group, demonstrating that there was no complications in the observation group. Conclusion The application of saxagliptin in the treatment of patients with type 2 diabetes mellitus with poor insulin control has a significant effect, which not only can reduce the daily consumption of insulin, but also can improve the insulin resistance effectively. Saxagliptin is worthy of further clinical application and promotion.
出处
《中国现代医生》
2017年第28期82-84,共3页
China Modern Doctor
关键词
沙格列汀
胰岛素
2型糖尿病
效果分析
安全性预测
Saxagliptin
Insulin
Type 2 diabetes mellitus
Analysis of effect
Prediction of safety
