摘要
基于超顺磁Fe_3O_4纳米粒子(SPIONs)的磁响应型纳米药物载体已经广泛应用于肿瘤诊断与治疗方面。将SPIONs用多功能性外壳修饰后,能够增加其稳定性,实现体内长循环,并能缓释出所携带药物;将其与靶向性配体分子复合后,能够提高其肿瘤多靶向的效果;通过将SPIONs用温敏性或光敏性等外壳材料包覆,利用SPIONs的磁致发热、光致发热以及外壳材料自身的特点,能够直接杀死肿瘤细胞或者将温敏性外壳剥落,平稳地释放出药物,提高肿瘤部位的药物浓度,增强治疗效果。本文综述了基于超顺磁Fe_3O_4的磁响应型纳米药物载体在肿瘤治疗领域的新研究与新进展,以期为今后相关方面的深入研究提供参考和借鉴。
The magnetic response nano-drug carriers based on superparamagnetic iron oxide nanoparticles（ SPIONs） have been widely used in tumor diagnosis and treatment. Their stability,circulation time and sustained drug release capability are all increased by function modification of the SPIONs. They are combined with targeted ligand molecules,which can enhance their multi-targeting effect. Based on magnetism-and photo-thermal effects of SPIONs and shell materials,they can directly kill tumor cells or peel off the thermo-sensitive shell to release drugs,increase the drug concentration in the tumor site,thereby enhancing the treatment effect of tumor. Herein the progress in the magnetic response nano-drug carriers based on SPIO was reviewed.
作者
支德福
白宇超
张琳
张树彪
Zhi Defu Bai Yuchao Zhang Lin Zhang Shubiao(Key Laboratory of Biotechnology and Bioresources Utilization, Ministry of Education, Dalian Minzu University, Dalian 116600)
出处
《化学通报》
CSCD
北大核心
2017年第11期987-994,1060,共9页
Chemistry
基金
国家自然科学基金项目(21503035
21606041
21176046)
国家863计划项目(2014AA020707)
中央高校自主科研基金项目(DC201502020205)
大连民族大学博士启动基金项目资助
