摘要
近年来生物免疫治疗已经广泛应用于临床各种恶性肿瘤,其中以肿瘤抗原负载的树突状细胞(DC)疫苗联合诱导的免疫活性细胞技术最成熟、应用最广泛。已知DC是功能最强大的抗原呈递细胞,在抗肿瘤免疫中起重要作用。DC与肿瘤的发生、发展密切相关,在联合传统治疗的基础上大大提高了恶性肿瘤患者的生存率。但DC在体内的作用及其特点尚不完全清楚,进一步明确DC在肿瘤微环境中的作用可为提高其生物治疗效果提供依据。
In recent years,bioimmunotherapies have been widely used in the clinical treatment of various malignant tumors,among which the tumor antigen loaded dendritic cells（ DC） vaccine combined immunocompetent cells technology is the most mature and most widely used. DC are known to be the most potent antigen-presenting cells and play an important role in anti-tumor immunity. DC is closely related to the occurrence and development of tumor,which greatly increases the survival rate of malignant tumor patients is greatly improved on the basis of combined traditional therapy. But the role of DC in the body and its characteristics are not entirely clear,and further clarification of the role of DC in the tumor microenvironment,will provide reference for improving the effect of biological treatment.
出处
《医学综述》
2017年第19期3785-3789,共5页
Medical Recapitulate
关键词
树突状细胞
生物治疗
微环境
Dendritic cell
Biological therapy
Microenvironment
