摘要
目的了解鲍曼不动杆菌的临床分布和耐药性的变迁,分析并比较血液分离菌株与痰液分离菌株的耐药率,为控制医院内感染及合理使用抗菌药物提供依据。方法收集2013年6月-2016年5月温州医科大学附属第一医院住院患者血液与痰液中分离的鲍曼不动杆菌共1 500株,分析其耐药率;并分析比较3年来痰液分离菌株对各种抗菌药物的耐药性是否有显著变化。结果鲍曼不动杆菌引起的感染无明显季节性,发病人群以中老年患者为主,主要分离自重症监护室。痰液分离菌株对所有临床常用抗菌药物的耐药率都明显高于血液分离菌株,痰液分离菌株对多种抗菌药物的耐药率逐年上升。结论鲍曼不动杆菌的临床分离率高,耐药情况严重,应加强细菌耐药监测。
Objective To investigate the clinical distribution and antimicrobial resistance changes,and analyze the resistance rate of isolates from blood and sputum,so as to provide basis for the rational use of antibiotics. Methods A total of 1 500 A.baumannii isolates were collected from blood and sputum of patients at the First Affiliated Hospital of Wenzhou Medical University from June 2013 to May 2016. The differences of resistance rates of A. baumannii isolates to antimicrobial agents were investigated. The shift in resistance rates of A. baumannii isolates from sputum to antimicrobial agents in 3 years was also analyzed.Results The infections caused by A. baumannii were not associated with season. Most of the patients with A. baumannii infections were quinquagenarian from ICU. The resistance rates of A. baumanniii isolates from sputum to antimicrobial agents were significantly higher than those from blood and increased year by year. Conclusion The clinical isolation rate and resistance rate of A. baumannii isolates are high and serious,so surveillance of bacterial resistance should be strengthened.
出处
《中国卫生检验杂志》
CAS
2017年第16期2417-2420,共4页
Chinese Journal of Health Laboratory Technology
关键词
鲍曼不动杆菌
医院感染
耐药率
Acinetobacter baumannii
Nosocomial infection
Drug resistance
