摘要
目的了解重症医学科住院患者分离出的鲍曼不动杆菌病原菌感染分布情况及耐药特点,为临床提供合理诊疗依据。方法收集2017年1月至2018年12月长治医学院附属和平医院重症医学科送检的1902例标本,采用自动化仪器及纸片扩散法分离病原菌,按照美国临床和实验室标准协会2017年发布的第27版折点标准进行药敏试验的结果判读。结果共分离1166株病原菌,其中鲍曼不动杆菌325株,占17.09%(325/1902);阳性标本主要来源于痰液(73.54%,239/325);药敏结果显示该菌对头孢哌酮/舒巴坦、左旋氧氟沙星、复方新诺明耐药率相对较低(45.40%~60.90%),对碳青霉烯类抗菌药物处于较高的耐药水平(2017年:69.20%,2018年:75.30%)。结论长治医学院附属和平医院重症医学科患者鲍曼不动杆菌感染率略高,存在多重耐药现象,需加强该病原菌药物监测并采取合理的管理措施,为临床合理选用抗菌药物提供依据。
Objective To understand the distribution and drug resistance of acinetobacter baumannii isolated from patients in the department of critical care,and to provide a reasonable basis for clinical diagnosis and treatment.Methods A total of 1902 specimens were collected from the department of critical care,Heping Hospital Affiliated to Changzhi Medical College from January 2017 to December 2018.The pathogens were isolated by automated instruments and paper diffusion method,and the results of drug susceptibility tests were interpreted according to the 27th edition of folding point standard released by the American association for clinical and laboratory standards in 2017.Results A total of 1166 pathogenic bacteria were isolated,including 325 strains of acinetobacter baumandii,accounting for 17.09%(325/1902).The positive samples were mainly from sputum(73.54%,239/325).The drug susceptibility results showed that the resistance rate of the bacteria to cefoperazone/sulbactam,levofloxacin and compound nephrine was relatively low(45.40%~60.90%),while the resistance to carbapenem antibiotics was relatively high(2017:69.20%,2018:75.30%).Conclusion The infection rate of acinetobacter baumannii in the intensive care unit of Heping Hospital Affiliated to Changzhi Medical College is slightly higher,and there is a phenomenon of multiple drug resistance.Therefore,it is necessary to strengthen the drug monitoring of this pathogen and take reasonable management measures,so as to provide a basis for rational clinical selection of antibiotics.
作者
李鹏
弓艳娥
韩素丽
杜园园
郭旭霞
Li Peng;Gong Yan′e;Han Suli;Du Yuanyuan;Guo Xuxia(Laboratory of Heping Hospital Affiliated to Changzhi Medical College,Changzhi 046000,China)
出处
《中华临床医师杂志（电子版）》
CAS
2019年第10期758-760,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
山西省高等学校科技创新项目(2019L0708)
关键词
重症医学科
鲍曼不动杆菌
病原体
感染
分布
耐药性
The department of critical care
Acinetobacter baumanni
Pathogen
Infection
Distribution
Drug resistance
