摘要
采用水溶液反应法,以不同粘均相对分子质量的聚六亚甲基双胍(PHMB)作为配体,合成出一系列稳定的由400 nm左右的小颗粒团聚而来的微米级四配位Ag(Ⅲ)-PHMB配合物,并对其进行表征证明了物质的结构与价态。通过抗菌活性实验发现,Ag(Ⅲ)-PHMB配合物的抗菌活性随着配体PHMB的粘均相对分子质量的升高而增大,随着粒径增大而减小。在低浓度条件下,微米级Ag(Ⅲ)-PHMB配合物的抗菌性能高于同等质量浓度的AgO、AgNO_3与PHMB;随着质量浓度的升高,微米级Ag(Ⅲ)-PHMB配合物与细菌的实际接触面积、缓释出的抗菌活性物质增长趋缓,因而抗菌活性升高趋缓。
As the ligand and biological acceptable parts, polyhexamethylene biguanide hydrochloride （PHMB） are used for stabilizing Ag^3＋. A series of micron-sized quadricovalent cationic Ag （ Ⅲ ）-PHMB complexes was synthesized via oxidation of the monovalent silver, followed by stabilization of the oxidized high valence silver ions through complexation with PHMB. From the experimental result of agar well-diffusion method, it can be concluded that the antibacterial activity of Ag （Ⅲ）-PHMB complex is enhanced with increasing viscosity-average relative molecular mass of PHMB and weakened with the increase of the size of Ag（ Ⅲ ） -PHMB complex. The experimental results reveal that the complex yields the maximum antibacterial activity when the viscosity-average relative molecular mass of ligand is 5428. Though broth dilution method, micron-sized Ag （ Ⅲ ）-PHMB complex displays excellent antibacterial performance in low mass concentration towards Gram-positive and Gram-negative prokaryotes for excellent antibacterial activity of Ag^3＋. Compared with AgO, AgNO3 and PHMB, Ag （ Ⅲ ）-PHMB complex has lower minimal inhibitory concentration （MIC）. With the increase of mass concentration, however, because of the reduction of the growth area between Ag （Ⅲ ）-PHMB complex and bacteria and the release radio of antimicrobial antibacterial activity of micron-sized Ag（ Ⅲ）-PHMB complex shows slowly increasing rate. ratio of contacting active substance,
出处
《应用化学》
CSCD
北大核心
2017年第7期749-756,共8页
Chinese Journal of Applied Chemistry
基金
环境友好类杀菌剂有机络合银关键技术的研发及产业化(2012B10023)
国家级大学生创新创业训练计划资助项目(201610386013)~~
关键词
Ag(Ⅲ)-聚六亚甲基双胍配合物
粘均相对分子质量
抗菌性能
Ag （Ⅲ）-polyhexamethylene biguanide hydrochloride complex
viscosity-average relativemolecular mass
antibacterial performance
