摘要
目的了解轮状病毒性腹泻患儿血清中肌酸激酶(CK)及肌酸肌酶MB同工酶(CK-MB)的变化规律,并探讨其与脱水酸中毒的关系。方法选取2013年3月至2016年5月于徐州市儿童医院就诊的轮状病毒性腹泻患儿179例作为研究对象,另外选取同期健康小儿53例作为正常对照组,非轮状病毒性腹泻患儿104例作为轮状病毒阴性对照组,测定所有幼儿血清中心肌酶谱各指标的表达水平,并进行不同程度脱水酸中毒的组间分析。结果轮状病毒性腹泻患儿血清中CK、CK-MB、HBDH及AST的水平均显著高于对照组和非轮状病毒感染性腹泻组(P<0.05),而LDH在不同类型小儿腹泻组间差异无统计学意义(P>0.05);CK、CK-MB及AST在不同程度脱水或酸中毒患儿血清中的表达差异有统计学意义(P<0.05),其中CK和CK-MB变化尤为明显;而HBDH和LDH在不同酸中毒程度时差异有统计学意义(P<0.05),但在不同脱水程度时差异无统计学意义(P>0.05)。结论轮状病毒性感染性腹泻患儿血清中CK、CK-MB的表达随着脱水或酸中毒程度的加重呈上升趋势,临床上可以通过脱水酸中毒程度预测腹泻患儿的心肌损伤程度,以便及早进行治疗,避免小儿病毒性心肌炎的发生。
Objective To investigate the expression of creatine kinase（CK）and creatine kinase MB isoenzyme（CK-MB）in serum of children with rotavirus diarrhea,and explore the relationship between serum levels of CK and CK-MB withdehydration and acidosis. Methods 179 cases of children with rotavirus diarrhea were selected in our hospital from March2013 to May 2016 as the study subjects;in addition,53 cases of healthy children were selected at the same period as normalcontrol group and 104 cases of children with non rotavirus diarrhea were selected as the negative control group. The levels ofcardiac kinases in serum of all children were measured and analyzed between different degrees of dehydration and acidosisgroups. Results The levels of CK,CK-MB,HBDH and AST in children with rotavirus diarrhea were significantly higherthan those in control group and non rotavirus infected diarrhea group（P〈0.05）,but the LDH level showed no statisticalsignificance between different types of diarrhea（P〉0.05）. The difference was statistically significant between the expression ofCK,CK-MB and AST in serum of children with different degrees of dehydration and acidosis（P〈0.05）;in which,thechanges of CK and CK-MB levels were obvious. There were statistically significant differences between the levels of HBDH andLDH in serum of children with different degree of acidosis（P〈0.05）,but no statistical significance was found in children withdifferent degrees of dehydration（P〉0.05）. Conclusions The expression levels of CK and CK-MB in children with diarrheawere on the rise with the aggravation of dehydration and acidosis. It could be used to predict the myocardial damage in childrenwith diarrhea by predicting the degree of dehydration and acidosis,so as to avoid the occurrence of viral myocarditis.
出处
《热带医学杂志》
CAS
2017年第4期487-490,共4页
Journal of Tropical Medicine
