摘要
目的探究EZSCAN无创筛查技术对糖尿病(DM)及糖耐量异常(IGT)的临床应用价值。方法选取葡萄糖代谢紊乱高风险人群(年龄大于或等于45岁,BMI≥25kg/m2)158例,采用EZSCAN无创筛查技术对筛查者进行糖尿病风险评估,并且对其行无水葡萄糖耐量试验(OGTT),检测其糖基化血红蛋白(HbA1c)及空腹血糖(FPG)水平。结果 158例筛查者中正常糖耐量者(NGT)96例,IGT患者39例,DM患者23例,3组患者EZSCAN值分别为(32±9)、(45±11)、(48±12)%,差异有统计学意义(P<0.05)。Pearson相关性分析表明EZSCAN值与2h-OGTT,HbA1c及FPG具有一定的相关性(r=0.513、0.701、0.552,P<0.01)。EZSCAN对IGT诊断的切点值为37.0%,敏感度为82.2%,特异性为62.7%,AUC为0.769,其对IGT的预判效能优于HbA1c和FPG;而EZSCAN对DM诊断切点为50.0%,敏感度为53.7%,特异性为58.4%,AUC为0.531,其对DM的预判效能不如HbA1c和FPG。结论 EZSCAN无创筛查技术能对IGT及DM进行早期筛查,对IGT的筛查效果较DM更加优越,对IGT的早期诊断具有重要的临床应用价值。
Objective To explore the clinical application value of EZSCAN noninvasive screening technique for diabetes mellitus（DM）and impaired glucose tolerance（IGT）.Methods One hundred and fifty-eight cases with high risk of glucose metabolic disorder（age≥45years old,BMI≥25kg/m2）were selected.The EZSCAN non-invasive screening technique was adopted to evaluate the DM risk in screened cases,and the anhydrous oral glucose tolerance test（OGTT）,was performed.The glycosylation hemoglobin（HbA1c）and fasting blood glucose（FPG）levels were detected.Results Among 158 screened cases,96 cases were normal glucose tolerance（NTG）,39 cases were IGT,23 cases were DM,the EZSCAN values in 3groups were（32±9）,（45±11）,（48±12）% respectively,the difference was statistically significant（P〈0.05）.The Pearson correlation analysis showed that the EZSCAN value has a certain correlation with 2h-OGTT,HbA1 cand FPG（r=0.533、0.401、0.202,P〈0.01）.The cut-off value of EZSCAN on IGT diagnostic value was 37%,the sensitivity was 82.2% and specificity was 62.7%,AUC was 0.769,its predictive efficiency on IGT was superior to HbA1 cand FPG;the cut-off value of EZSCAN for DM diagnostic was 50.0%,the sensitivity was 53.7%and specificity was 58.4%,AUC was 0.531,its predictive efficiency on DM was worse than those of HbA1 cand FPG.ConclusionThe EZSCAN noninvasive screening techniques can screen early IGT and DM and its screening effect to IGT is more superior to DM screening,which has an important clinical application value for early diagnosis of IGT.
出处
《重庆医学》
CAS
北大核心
2017年第3期362-365,共4页
Chongqing medicine
