摘要
目的:研究类风湿关节炎(RA)患者血清中血管内皮细胞生长因子(VEGF)的水平及其临床意义。方法:采用酶联免疫吸附试验(ELISA)方法检测RA活动组(73例)、RA缓解组(39例)及健康对照组(52例)的血清VEGF的质量浓度,分析血清VEGF质量浓度与RA病情活动指标之间的关系。结果:RA活动组的血清VEGF质量浓度明显高于健康对照组,差异有统计学意义(P<0.01);RA活动组患者的血清VEGF质量浓度明显高于RA缓解组患者和健康对照组,差异有统计学意义(P<0.01),RA缓解组血清VEGF质量浓度和健康对照组比较差异无统计学意义(P>0.05)。C反应蛋白(CRP)和关节疼痛数与VEGF质量浓度呈明显正相关关系(P<0.01)。结论:血清VEGF质量浓度在RA患者中明显升高,且与病情具有相关性,在临床上可作为RA病情判断和疗效评估的指标之一。
Objective： To investigate the serum vascular endothelial growth factor （VEGF） level in rheumatoid arthritis（RA） patients and its clinical significance. Methods： 112 patients with RA and 52 healthy controls were enrolled in this study. The serum concentration of VEGF was determined by enzyme-linked immunosorbent assay （ELISA）. Results： The serum VEGF level in patients with active RA was significantly higher than that in clinical remission RA patients and healthy controls （ P d0.01）. There was no statistical difference in VEGF level between clinical remission RA patients and healthy controls （ P 〉0.05）. The VEGF concentration was positively associated with the C-reactive protein （CRP） level and arthralgia counts （ P 〈0.01）. Conclusion： There was a positive correlation between the serum VEGF concentration and RA condition. The serum VEGF level could be a potential marker for evaluating the severity of RA.
出处
《广西医科大学学报》
CAS
2017年第1期20-23,共4页
Journal of Guangxi Medical University
基金
首都医学发展科研基金资助项目(No.2009-3221)
关键词
类风湿关节炎
血管内皮生长因子
相关性
rheumatoid arthritis
vascular endothelial growth factor
correlation
