摘要
运动调控骨代谢的过程十分复杂,涉及多条信号通路。大量离体研究表明,机械应力通过Wnt、骨形态发生蛋白(BMP)及骨保护素(OPG)/核因子κB受体活化因子配体(RANKL)/核因子κB受体活化因子(RANK)等骨代谢信号通路对骨代谢进行调控,其强度、频率等均会对骨组织细胞产生不同的影响。众多在体实验也证实,运动通过调节相关骨代谢信号通路的关键因子进一步影响骨代谢。本文主要阐述运动对骨代谢信号通路的影响及其作用机制。
The process of exercise regulating bone metabolism is complicated, which involves a number of signaling pathways. A large number of studies in vitro have indicated that mechanical stress regulates bone metabolism by Wnt, bone morphogenetic protein（BMP）, and osteoprotegerin（OPG）/ receptor activator of NF-κB ligand（RANKL）/ receptor activator of NF-κB（RANK） signaling pathways. Both the intensity and frequency of mechanical stress have varing impact on bone tissue and cells. Plenty of studies in vivo also have shown that exercise regulates bone metabolism by key factors in bone metabolism signaling pathways. This paper reviewed the effects of exercise on bone metabolism pathways and their mechanisms.
出处
《中国康复理论与实践》
CSCD
北大核心
2016年第12期1425-1429,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金项目(No.81572242)
上海市人类运动能力开发与保障重点实验室项目(上海体育学院)(No.11DZ2261100)
关键词
运动
机械应力
骨代谢信号通路
综述
exercise
mechanical stress
bone metabolism pathway
review
