摘要
具备个性化、精准化的3D生物打印技术构建优良生物相容性的组织工程支架,替换或修复人体中病变的组织和/或器官,在组织工程研究中极具广泛的应用前景。而作为3D打印技术的基材,如金属、生物陶瓷、高分子材料和细胞生物材料等,也因此得到了研究者的重视和研发。由金属和生物陶瓷制备的支架具有高强度和耐腐蚀性,已在骨科中得到广泛应用,而高分子材料由于其和细胞/组织的良好生物相容性及可塑性使其在软骨、矫形外科、心血管系统等组织/器官中被广泛研究。相信在不久的将来,以上述材料为基材结合3D生物打印技术构建的组织和器官,在临床上会得到应用和推广。本文就用于3D打印的生物材料及其打印技术在组织工程支架构建及组织再生中的应用进行综述。
3D bio-printing technology with the characteristics of individualization and precision has been inten- sively studied to fabricate the biocompatible tissue engineered scaffolds, towards replacing or repairing of the diseased tissues or/and organs in human body. Biomaterials including metals, biological ceramics, polymers and cell-related materials were studied to be used as the matrixes of 3D bioprinting. Scaffolds prepared from metals and ceramics have been widely applied in bone regeneration due to their high strength and good corro- sion resistance. Whilst, scaffolds from polymers and cell-related biological materials were researched to be ap- plied in repairing of orthopedics and cardiovascular system due to their good plasticity and biocompatibility. It can be expected that all these researches, including the biomaterials and 3D bioprinting, will be employed in clinic in the near future. In this paper, the applications of 3D bioprinting and biomaterials in preparing tissue engineered scaffolds and in tissue regeneration were reviewed.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2016年第6期462-468,共7页
Space Medicine & Medical Engineering
基金
国家自然科学基金(81471797)
宁波市创新团队项目(2015B11050)
关键词
3D生物打印
组织工程
支架构建
生物材料
组织再生
three-dimensional bioprinting
tissue engineering
scaffold constitution
biomaterials
tissue regen-eration
