摘要
目的探讨妊娠不同时期血脂正常参考值范围及临床分析结果在其中的应用。方法选取2014年6-12月在该院生产的足月单胎孕妇为研究对象,对其进行问卷调查,最终符合纳入该研究病例2 117例。将正常孕妇血脂排序,求出相应百分位数,将逢5整倍数百分位上的具体血脂数值作为诊断临界值,采用诊断实验分别求出相应的总符合率π,将得出最佳符合率百分位数的具体血脂值作为最佳临界值,建立血脂正常值参考区间。结果适合该地区的正常妊娠血脂参考值范围为:孕早期:总胆固醇(TC)≤4.93 mmol/L,甘油三酯(TG)≤1.18 mmol/L,高密度脂蛋白(HDL)≥1.75 mmol/L,低密度脂蛋白(LDL)≤2.33 mmol/L;孕中期:TC≤7.17 mmol/L,TG≤2.46 mmol/L,HDL≥1.75 mmol/L,LDL≤4.99 mmol/L;孕晚期:TC≤7.02 mmol/L,TG≤3.25 mmol/L,HDL≥1.65 mmol/L,LDL≤5.17 mmol/L。结论在分析临床结果的基础上定义正常参考值范围,更符合妊娠期血脂变化特征,对临床监测孕妇孕期血脂水平,改善妊娠结局,具有较好的参考价值。
Objective To explore the normal reference value ranges of serum lipids during different periods of pregnancy and the appli- cation of clinical analysis results. Methods The full-term single pregnant women who gave birth to their babies in the hospital from June to December in 2014 were selected and surveyed by a questionnaire, 2 117 pregnant women were included according to inclusion criteria final- ly. The serum lipids of normal pregnant women were sorted, the corresponding percentiles were calculated, taking specific blood lipids values of every five euploid percentile as diagnostic critical values, the total coincidence rates （π） were calculated by laboratory diagnosis. Specific blood lipids values of percentile at the optimal coincidence rate was considered as the optimal critical value, then the normal reference value ranges of serum lipids were established. Results The normal reference value ranges of serum lipids suitable for the pregnant women in local area： during the first trimester of pregnancy： total cholesterol （TC） ≤4. 93 mmol/L, trigtyceride （TG） ≤ 1.18 mmol/L, high-density lip- oprotein （HDL） ≥ 1.75 mmol/L, low-density lipoprotein （LDL） 42. 33 mmol/L; during the second trimester of pregnancy： TC ≤ 7.17 mmol/L, TG ≤ 2.46 mmol/L, HDL ≥ 1.75 mmol/L, LDL ≤ 4. 99 mmol/L; during the third trimester of pregnancy： TC ≤ 7.02 mmol/L, TG ≤ 3.25 mmol/L, HDL ≥ 1.65 mmol/L, LDL ≤5.17 mmol/L. Conclusion Defining normal reference value ranges based on the clinical analysis is more in line with the changing features of serum lipids during pregnancy, monitoring blood lipid levels of pregnant women can improve pregnancy outcome, the reference value is high.
出处
《中国妇幼保健》
CAS
2016年第21期4408-4411,共4页
Maternal and Child Health Care of China
基金
2014年度首都卫生发展科研专项项目基金资助(首发2014-4-7084)
关键词
妊娠
血脂
参考值
Pregnancy
Blood lipid
Reference value
