摘要
染料木素作为一种"植物雌激素",能促进成骨细胞增殖、分化和矿化骨形成功能,也能够抑制破骨细胞骨吸收过程,存在多种抗骨质疏松的分子机制。该文综述染料木素抗骨质疏松作用及其机制的研究进展,为研究与开发抗骨质疏松新药提供依据。
Genistein, as one kind of phytoestrogens, can stimu-late osteoblastic proliferation, differention and mineralization, and can also inhibit bone resorption activity of osteoclast. The effect of genistein on bone metabolism lies in various molecular mechanisms. This paper reviews the research progress of the an-ti-osteoporotic action of genistein and its mechanism, which may provide a basis for the research and development of new agents to treat osteoporosis.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2016年第10期1345-1348,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81273518
81673814)
广东省科技计划项目(No 2012B060300027
No 2016A020215148)
广东医学院科技创新基金项目(No STZF 101104)
