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维生素D对骨髓基质干细胞成骨分化的分子调控研究进展 被引量：6

Research progress on molecular regulatory effects of vitamin D on osteogenic differentiation of bone marrow stromal cells
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摘要 骨髓基质干细胞(MSCs)是骨髓基质的组成成分,在骨骼的发育和代谢平衡中起重要作用。该文总结并综述了维生素D及其活性形式1,25二羟基维生素D_3[1,25(OH)_2D_3]通过Wnt信号通路、Wnt5a/ROR2轴、BMP/TGF-β/Samd信号通路、ROS/ERK信号通路对MSCs成骨分化的分子调控,阐明了维生素D对MSCs代谢调控的分子信号通路。 Marrow stromal cells （ MSCs） , component of the mar-row stroma, play an important role in the growth of bone and metabolic balance. This paper mainly summarizes and reviews the molecular regulaory effects of vitamin D and its active form 1, 25 dihydroxy vitamin D3[1,25（OH）2D3] on the osteogenet-ic differentiation of MSCs by Wnt signaling pathway, Wnt5a/ROR2 axis, BMP/TGF-β/Samd signaling pathway and ROS/ERK signaling pathway, so as to clarify the molecular signaling pathway through which vitamin D regulates MSCs metabolically.
作者 张尧 李晓莉 张岩
机构地区 上海理工大学系统生物医学研究中心 上海中医药大学附属龙华医院
出处 《中国药理学通报》 CAS CSCD 北大核心 2016年第10期1337-1340,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 81202894) 龙医创新团队计划项目(No LYCX-01)
关键词 维生素D 1 25(OH)2D3 骨髓基质干细胞 分子调控 信号通路 成骨分化 vitamin D 1 ,2 5 （ OH）2D3 marrow stromal cells molecular regulation signaling pathway osteogenic differentia-tion
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
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参考文献8

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  • 1De-Ren Fang,Zhong-Fa Lv,Gang Qiao.Dynamic Wnt5a expression in murine hair follicle cycle and its inhibitory effects on follicular in vivo[J].Asian Pacific Journal of Tropical Medicine,2014,7(4):285-288. 被引量：2
  • 2Roel NUSSE.Wnt signaling in disease and in development[J].Cell Research,2005,15(1):28-32. 被引量：86
  • 3Heikkinen S, Vaisinen S, Pehkonen P,et al. Nuclear hormone I c, 25-dihydroxy-vitamin D3 elicits a genome-wide shift in the loca- tions of VDR chromatin occupancy [ J ]. Nucleic Acids Res, 2011, 39(21) :9181-9193.
  • 4Malloy PJ, Peng L, Wang J, et al. Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibi- ting substance (MIS) promoter: regulation of MIS expression by ealeitriol in prostate cancer cells [ J ]. Endocrinology, 2009, 150 (4) :1580-1587.
  • 5Lisse TS,Hewison M, Adams JS. Hormone response element bind- ing proteins: novel regulators of vitamin D and estrogen signaling [ J ]. Steroids,2011,76 (4) :331-339.
  • 6Szrles L, P61iska S, Nagy G,et al. Research resource : transeriptome profiling of genes regulated by RXR and its permissive and nonper- missive partners in differentiating monocyte-derived dendritic cells [ J]. Mol Endocrino1,2010,24( 11 ) :2218-2231.
  • 7Meyer MB, Goetsch PD, Pike JW. Genome-wide analysis of the VDR/RXR cistrome in osteoblast cells provides new mechanistic insight into the actions of the vitamin D hormone [ J ]. J Steroid BiochemMol Biol,2010,121 ( 1/2) : 136-141.
  • 8Perakyla M. Ligand unbinding pathways from the vitamin D recep- tor studied by molecular dynamics simulations[ J]. Eur Biophys J, 2009,38(2) :185-198.
  • 9Oda Y, Uchida Y,Moradian S,et al. Vitamin D receptor and coae- tivators SRC2 and 3 regulate epidermis-specific sphingolipid pro- duction and permeability battier formation [ J ]. J Invest Dermatol, 2009,129 ( 6 ) : 1367-1378.
  • 10Sieinska W, Rntkiewicz P. Structural changes of vitamin D reeeptnr induced by 20-epi-I alpha,25-(OH) 21)3 : an insight from a com- putational analysis [ J ]. J Steroid Bioehem Mol Biul, 2009,113 ( 3/ 5 ) :253-258.

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中国药理学通报
2016年 第10期

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