摘要
目的探讨自体肿瘤免疫细胞(DC-CIK)辅助介入治疗中晚期原发性肝癌临床效果。方法 2013年1月至2015年6月我院76例中晚期原发性肝癌患者,采用随机数字表法将其分为观察组和对照组,每组38例。对照组采取单纯介入治疗,观察组则行自体DC-CIK细胞辅助介入治疗,比较2组近期疗效、不良反应、治疗前后肝功能指标、甲胎蛋白(AFP)及免疫功能变化。结果 2组近期有效率、不良反应发生率比较,差异无统计学意义(P>0.05)。观察组治疗后AST、ALT、AFP水平分别为(30.4±6.0)u/L、(45.2±3.8)u/L、(168.5±49.3)mg/L,均显著低于对照组的(65.1±6.3)u/L、(61.8±5.3)u/L、(315.2±39.5)mg/L,2组比较差异有统计学意义(P<0.05)。观察组治疗后CD3+、CD4+、CD4+/CD8+均明显高于对照组,差异有统计学意义(P<0.05)。结论自体DC-CIK细胞辅助介入治疗能明显改善中晚期原发性肝癌患者肝功能,降低肿瘤标志物AFP水平,显著提高患者免疫功能。
Objective To investigate the clinical effects of autologous tumor immune cells （DC-CIK） assisted interventional therapy in the treatment of advanced primary liver cancer. Methods Totally 76 patients with advanced primary liver cancer were divided into 2 groups with 38 cases in each group by random number table method. The control group were merely treated with interventional therapy while the ob- servation group were treated with autologous DC-CIK cell assisted interventional therapy. The short-term curative effect, adverse reactions,liver function indexes before and after treatment, alpha fetal protein （AFP） and changes of immune function were compared between the 2 groups. Results There was no statistically significant difference in short-term curative effect and incidence of adverse reactions between the 2 groups （ P 〉 0.05 ）. After treatment, the levels of AST, ALT and AFP in the observation group [ （ 30.4 ± 6.0 ） u/L, （ 45.2±3.8 ） u/L, （ 168.5 ± 49.3 ） mg/L] were significantly lower than those in the control group [ （ 65.1 ±6.3 ） u/L, （ 61.8± 5.3 ） u/L, （ 315.2 ± 39.5 ） mg/L], and the differences were statistically significant （ P 〈0. 05 ）. After treatment, CD3 ＋ , CD4 ＋ and CD4 ＋/CD8 ＋ in the observation group were significantly higher than those in the control group （ P 〈 0.05 ）. Conclusion Autologous DC-CIK cell assisted interventional therapy can sig- nificantly improve the liver function of patients with advanced primary liver cancer, and it can reduce the level of tumor marker AFP and sig- nificantly improve the immune function of patients.
出处
《局解手术学杂志》
2016年第10期762-765,共4页
Journal of Regional Anatomy and Operative Surgery
