摘要
目的 探讨早期使用丁苯酞注射液治疗基底节区脑梗死对侧支循环建立及神经功能的影响。方法 根据治疗方法将121例基底节区脑梗死患者分为丁苯酞组53例和对照组68例。两组患者给予脱水剂,胃黏膜保护剂、抗血小板聚集药、调脂药、扩血管药、活血化瘀中药、脑保护药物及其他对症支持治疗,丁苯酞组于发病24 h内加用丁苯酞注射液100 ml,静脉滴注2次/d。于入院第4~5 d采用CTA检查观察所有患者侧支循环的建立情况。于入院时、第2周及第3个月进行NIHSS评分。结果 丁苯酞组37例（69.8%）建立侧支循环,对照组38例（55.9%）建立侧支循环。丁苯酞组侧支循环建立率显著高于对照组（P〈0.05）。丁苯酞组及对照组入院时NIHSS评分差异无统计学意义（P〉0.05）。与丁苯酞组比较,对照组第2周及第3个月NIHSS评分显著升高（P〈0.05~0.01）。结论 早期使用丁苯酞注射液治疗的基底节区脑梗死患者可促进脑梗死部位的侧支循环的建立,减轻脑梗死症状,改善预后。
Objective To explore the influence of early use of dl-3-n-butylphthalide on the neurologic function and the establishment of collateral circulation after the treatment in patients with basal ganglia cerebral infarction.Methods According to treatment, 121 basal ganglia cerebral infarction patients were divided into dl-3-nbutylphthalide group（ 53 cases） and control group（ 68 cases）. Two groups were treated with gastric mucosal protective drug,platelet aggregation inhibitor,lipid- lowering drug,vascular dilation drug,Chinese medicine for blood-activiating and stasis-dissolving drugs,brain-protection drugs as supporting treatment. Patients in dl-3-nbutylphthalide group were additionally treated with 100 ml dl-3-n-butylphthalide by intravenous drip twice a day within 24 h after attack. CTA testing was used to establish collateral circulation of all patients 4- 5 d after admission.And NIHSS were recorded at admission,2nd week and 3rd month. Results Thrity-seven patients（ 69. 8%） in dl-3-n-butylphthalide group established collateral circulation,while 38 patients（ 55. 9%） in control group established collateral circulation. The rate of collateral circulation in dl-3-n-butylphthalide group was significantly higher than that in control group（ P 0. 05）. The difference of NIHSS scores between the two groups showed no statistical significance on admission（ P 0. 05）. Compared with dl-3-n-butylphthalide group,the NIHSS scores in control group were significantly increased at 2nd week and 3rd month（ P 0. 05- 0. 01）. Conclusion Early use dl-3-nbutylphthalide for the patients with basal ganglia cerebral infarction can promote the collateral circulation in cerebral infarction area,relieve the symptoms of cerebral infarction,and improve the prognosis.
出处
《临床神经病学杂志》
CAS
北大核心
2016年第4期293-295,共3页
Journal of Clinical Neurology
关键词
基底节区脑梗死
丁苯酞注射液
侧支循环
NIHSS评分
CTA
basal ganglia cerebral infarction
dl-3-n-butylphthalide injection
collateral circulation
NIHSS score
CTA
