摘要
目的探讨E-选择素、CD14及血管细胞粘附分子(vascular cell adhesion molecule 1,VCAM1)水平与生殖道沙眼衣原体感染的相关性。方法选取86例生殖道沙眼衣原体感染患者为观察组;根据生殖道沙眼衣原体感染患者是否伴有炎症,分为感染伴炎症组和感染无炎症组,各43例;同时,选取36例健康体检者为对照组;采用双抗体夹心酶联免疫吸附法(ELISA)测定所有研究对象的血清E-选择素、CD14及VCAM1水平,并作对比分析;观察组患者采取炎克宁冲剂结合阿奇霉素治疗,对比治疗前后的血清E-选择素、CD14及VCAM1水平,并与对照组作对比分析。结果观察组的血清E-选择素、CD14及VCAM1水平均显著高于对照组;差异具有统计学意义(P<0.05);感染伴炎症组与感染无炎症组的血清E-选择素、CD14及VCAM1水平的差异具有统计学意义(P<0.05);观察组患者采取炎克宁冲剂结合阿奇霉素治疗后,临床总有效率为94.19%,生殖道沙眼衣原体转阴率为87.21%;治疗后的血清E-选择素、CD14及VCAM1水平显著低于治疗前水平,差异具有统计学意义(P<0.05);与对照组对比,差异无统计学意义(P>0.05)。结论生殖道沙眼衣原体感染的病情进展与E-选择素、CD14及VCAM1水平密切相关,通过监测E-选择素、CD14及VCAM1水平,可为生殖道沙眼衣原体感染的治疗、评估疗效及预后而提供依据。
Objective To investigate the correlation between E-selectin, CD14 and VCAM1 and genital Chlamydia trachomatis infection. Methods A total of 86 patients with genital Chlamydia trachomatis infection were selected as the observation group. Patient were divided into two groups based on the degree of inflammation. Each group had 43 patients. In one group, patients had infection and inflammation. In the other group, patients had infection and no inflammation. We included 36 healthy people as the control group. The levels of E-selectin, CD14 and VCAM1 were detected by ELISA and compared among groups. Patients in the observation group received the treatment of yankening powder and azithromycin. And the levels of E-selectin, CD14 and VCAM1 were compared and analyzed before and after treatment. Results The levels of E-selectin, CD14 and VCAM1 in the observation group were higher than those in the control group. And there was a significant difference between groups （P〈0.05）. The levels of E-selectin, CD14 and VCAM1 were significantly different between the infection/ inflammation group and the infection /no- inflammation group （P〈0.05）. After treatment, the total effective rate in the observation group was 94.19% and the negative conversion of genital Chlamydia trachomatis was 87.21%. There was no significant difference for levels of E-selectin, CD14 and VCAM1 after treatment when compared to that of control group. And the levels of E-selectin, CD14 and VCAM1 were significant lower than those before treatment. Conclusion E-selectin, CD14 and VCAM1 were correlated with the development of genital Chlamydia trachomatis infection. The detection of these factors could provide foundation for the treatment, evaluation and prognosis of the disease.
出处
《标记免疫分析与临床》
CAS
2016年第7期760-762,765,共4页
Labeled Immunoassays and Clinical Medicine
基金
广东省科学技术厅项目
编号:2013B022000011
