摘要
目的：探讨表皮生长因子（Epidermal growth factor,EGF）对生殖道沙眼衣原体（Chlamydial Trachomatis,CT）感染的作用。方法：将48例沙眼衣原体生殖道感染小鼠模型随机分成两组,感染小鼠用EGF干预（试验组）,计算干预后第8天、18天、28天、38天CT感染率和感染小鼠阴道脱落菌量,并与生理盐水干预组（对照组）比较。结果：沙眼衣原体动物感染模型制备成功;干预后8~18天试验组感染率（45.8%,33.3%）显著低于对照组（79.2%,75%）;感染小鼠阴道脱落菌量〔（4.638±0.398）,（2.658±0.267）〕明显高于对照组〔（3.180±0.419）,（1.705±0.189）〕,两组有显著性差异;干预后28天两组感染率（12.5%vs 25%）及感染小鼠阴道脱落菌量〔（1.472±0.188）vs（1.112±0.233）〕无显著差异;干预38天两组感染率为0,感染小鼠阴道无脱落菌量。结论：EGF能明显降低CT感染的发生率和降低衣原体的毒力,从而为预防衣原体感染开辟了新途径。
Objective： To study the effeetion of EGF＇s on genital track infection from Chlamydial Traehomatis （CT） . Methods： 48 cases of 12 week - old mice infected by CT were divided into two groups randomly which were called experiment group and control group. The experiment group was treated with EGF, and the control group with saline respectively. The ehlamydial shedding and the infection rate were studied on 8 d, 18 d, 28 d and 38 d after being infected. Results： We set up a successful CT infection model. The infection rate on 8d, 18d in experiment group were lower （45. 8 %, 33. 3 % ） than in the control group （79. 2% , 75% ） ; CT shedding were higher in experiment group （4. 638 ±0. 398, 2. 658±0. 267） than in the control group （3. 180 ±0. 419, 1. 705 ±0. 189）. There were all significant differences. The ehlamydial shedding and the infection rate on 28 d and 38 d in the two groups had no significant differences. Conclusion： EGF can successfully prevent the Genital track infection from CT.
出处
《中国妇幼保健》
CAS
北大核心
2007年第19期2686-2688,共3页
Maternal and Child Health Care of China
