摘要
中医辨证论治强调对患者进行个体化治疗,与现代医学所倡导的精准治疗有相通之处。中医体质与证候部分由先天禀赋决定,即遗传发挥了重要影响。全基因组关联分析可直接将基因变异性与疾病或生理性状相关联,全表型组关联分析可进一步获得特定的遗传变异位点所影响的不同表型。未来中医药研究中,可以通过全基因组关联分析和全表型组关联分析从全基因组的层面上来判别影响特定体质、证候与病证结合对证治疗的分子遗传基础,揭示中医辨证论治的现代生物学本质,为提高中医诊断与治疗的精准性与稳定性提供参考。
Chinese medicine syndrome differentiation treatment emphasizes individualized treatment on patients,which is similar to precision treatment proposed by modern medicine. Chinese medicine constitution and syndrome is determined partly by natural endowment,which means that inheritance plays an important role. Genomewide association study could correlate gene mutation with disease or physiological characteristics directly. Phenomewide association study could further find out different phenotypes influenced by specific genetic variation site. In future Chinese medicine researches,molecular genetic basis,which is influenced by certain constitution,syndrome and disease-syndrome combination syndrome treatment,might be differentiated from genomewide aspect by genomewide association study and phenomewide association study. The essence of modern biology of Chinese medicine syndrome differentiation treatment might be revealed. This paper might provide reference for improving the precision and stability of Chinese medicine diagnosis and treatment.
出处
《中医杂志》
CSCD
北大核心
2016年第14期1191-1194,共4页
Journal of Traditional Chinese Medicine
基金
江苏省自然科学基金(BK20141565
BK20151568)
江苏省高层次创新创业人才引进计划
关键词
全基因组关联分析
全表型组关联分析
精准医学
中医证候
中医体质
基因表型
genomewide association study
phenomewide association study
precision medicine
Chinese medicine syndrome
Chinese medicine constitution
gene phenotype
