摘要
目的观察不同类型急性冠状动脉综合征患者血清S100B、MCP-1、COX2和高敏C反应蛋白(hs-CRP)等因子的表达水平,探讨其与不同类型冠脉综合征的相关性以及诊断意义。方法选择急性冠状动脉综合征患者134例,根据诊断分为急性心肌梗死(AMI)组55例,不稳定性心绞痛(UAP)组69例,另选取61例稳定性心绞痛患者作为SAP组,及健康体检者45名为健康对照组。运用酶联免疫吸附试验(ELISA法)测定血清S100B、MCP-1、COX-2及hs-CRP水平。结果AMI组和UAP组S100B、MCP-1、COX2和hs-CRP等因子的表达水平明显高于健康对照组;SAP组MCP-1,hs-CRP明显高于健康对照组,差异有统计学意义(P<0.01),COX2水平与健康对照组差异无统计学意义。AMI组和UAP组S100B、MCP-1、COX2和hs-CRP水平明显高于SAP组,差异有统计学意义(P<0.05)。结论 S100B、COX2可作为急性冠状动脉综合征斑块稳定性病变严重程度的预测因子,调节S100B及COX2可能成为治疗冠脉综合症的潜在靶点。
Objective To detection the serum level of S100B, MCP-1, COX-2 and high-sensitivity C-reactive protein（hs-CRP） in patients with different types of acute coronary syndrome, and to explore the correlation of these inflammatory cytokines with different types of coronary syndrome. Methods total of 134 patients with acute coronary syndrome were divided into two groups： acute myocardial infarction （AMI）group, 55 cases, unstable angina pectoris （UAP）group, 69 cases. We also selected 61 cases of stable angina pectoris as SAP group, and enrolled 45 age and gender marched healthy cases as healthy control group. Enzyme-linked immunosorbent assay（ELISA）was used to determine the expression of S100B, MCP-1, COX-2 and hs-CRP level. Results The expression level of S100B, MCP-1, COX-2 and hs-CRP is higher in the AMI and UAP groups than that in control group （P 〈 0.05 ）. The serum level of MCP- 1 and hs- CRP in SAP group is higher than that in control group. S100B and COX-2 in SAP group had no difference with control group. The level of S100B MCP1 ,COX-2 and hs-CRP in the UAP group was higher than that in SAP group,the difference was statistically significant （P 〈 0.05 ）. Conclusion S100B, MCP- 1, COX- 2 and hs- CRP have a close relationship to ACS and S100B and COX-2 can be used as predictors of stability of the plaques and severity of ACS.
出处
《标记免疫分析与临床》
CAS
2016年第6期672-675,共4页
Labeled Immunoassays and Clinical Medicine
