摘要
[目的]探讨DNA聚合酶β表达对食管癌放疗敏感性的影响及预后评估。[方法]收集85例食管癌患者,根据DNA聚合酶β（DNA polβ）的表达水平随机分为高表达常规分割组、高表达超分割组、低表达常规分割组和低表达超分割四组。常规分割：2Gy/f,总量56-64Gy/28-32次,超分割：1.3 Gy/f,2f/d,总量56-62Gy/43-48次。治疗中及治疗后随访,观察急性反应、晚期反应以及近期疗效、局控率及1、3年生存率。[结果]四组之间放疗晚期反应肺纤维化及食管狭窄差别无统计学意义（P=0.887、0.711）;近期疗效差异无统计学意义（P=0.862）;急性反应放射性气管炎、放射性食管炎差异有意义（P=0.049、0.031）,超分割两组显著高于常规分割组;1、3年局部控制率及生存率两组差异明显（P=0.028、0.036、0.040、0.014）。[结论]超分割放疗加重急性反应,DNA polβ表达不同对放疗敏感性有影响,低表达组超分割放疗预后相对较好。
[Objective] To explore the influence of DNA polymerase beta expression on the susceptibility to esophageal cancer radiotherapy and prognostic. [Methods] A total of 85 patients were divided into four groups according to the expression of polβ：high expression of conventional segmentation group,high expression of hyperfractionation groups,lower expression of conventional segmentation group and lower expression of hyperfractionation group. Conventional fractionation group：2Gy/f,DT56-64Gy/28-32f. Hyperfractionated group：1.3Gy/f,2f/d,DT56-62Gy/43-48f. The acute reaction,late effects,short-term effects,local control rate and 1-,3-year survival rate were observed. [Results] Late radiation pulmonary fibrosis and esophageal stenosis had no significant difference in the 4 groups（P=0.887,0.711）. The recent curative effect had no significant difference（P=0.862）. Acute radioactive reaction tracheitis,radioactive esophagitis had significant difference（P=0.049,0.031）. 1-,3-year local control and survival rate had obvious difference（P=0.028,0.036,0.040,0.036）. [Conclusion] Super segmentation radiation might increase acute reaction. Different expression of DNA pol beta may affect sensitivity to radiotherapy. Ultra low expression group divided radiotherapy has a better prognosis.
出处
《肿瘤学杂志》
CAS
2016年第4期305-309,共5页
Journal of Chinese Oncology
基金
山东省泰安市科技发展专项计划(201440774-43B)
