摘要
目的分析子痫前期与2个血栓形成基因单核苷酸多态性——凝血因子VG1691A和凝血因子IIG20210A之间的关系。方法使用Pubmed和Embase系统搜索2015年11月前相关文献,搜索关键词包括:子痫前期、血栓形成、凝血因子V Leiden、凝血酶原基因20 210及其之间不同排列组合。对入选文献进行Meta分析。结果共有37项研究中的5 048名重度子痫前期患者和6 796名健康对照者被纳入Meta分析中。结果显示凝血酶原G20210A基因多态性与所有类型子痫前期风险增加有关,而与重度子痫前期关联尤为密切。凝血因子V突变与所有类型子痫前期风险增加有关,而与重度子痫前期关联尤为密切。结论凝血因子VG1691A和凝血因子IIG20210A单核苷酸多态性与所有类型子痫前期和重度子痫前期风险增加有关。
Objective To estimate the relationship between the risk of preeclampsia and two thrombophilia gene single-nucleotide polymorphisms（SNPs）： the factor V G1691 A SNP and the prothrombin G20210 A SNP. Methods A systematic search of the literatures up to November 2015 was performed by using Pubmed and Embase. Search terms included＂preeclampsia,＂＂thrombophilia,＂＂factor V Leiden,＂＂prothrombin gene 20210,＂and their combinations. Meta analysis was conducted based on these data. Results A total of 37 studies in 5 048 patients with severe preeclampsia and 6 796 healthy controls were included in the Meta analysis. The results showed that the prothrombin G20210 A polymorphism was associated with an increased risk of all types of preeclampsia, and was particularly associated with severe preeclampsia. Coagulation factor V mutations are associated with an increased risk of all types of preeclampsia, and are particularly associated with severe preeclampsia. Conclusion This meta-analysis supports that the factor V G1691 A SNP and the prothrombin G20210 A SNP are associated with an increased risk for both preeclampsia overall and severe preeclampsia.
出处
《中国城乡企业卫生》
2016年第4期6-11,共6页
Chinese Journal of Urban and Rural Enterprise Hygiene
基金
天津市卫生局科技基金(2012KZ006)
关键词
荟萃分析
基因多态性
子痫前期
Meta-analysis
Gene polymorphism
Pre eclampsia
