摘要
目的研究布加综合征(BCS)患者凝血因子V Leiden突变(FVLeiden)及凝血酶原基因G20210A突变(FⅡG20210A)的情况及其与BCS发病的相关性。方法利用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)对比检测49例BCS患者及70例健康对照者FVLeiden及 FⅡG20210A突变情况。结果 45例中国汉族散发性BCS患者、两对家族性BCS患者及70例汉族健康对照个体未发现有F V Leiden及F ⅡG20210A突变。结论我国汉族BCS患者未发生 FVLeiden及FⅡG20210A突变,BCS的发病与FVLeiden及FⅡG20210A突变无相关性。
Objective To explore Factor Ⅴ Leiden and Factor Ⅱ G20210A mutations in Budd- Chiari syndrome （BCS）. Methods Forty-nine BCS patients including two pairs of siblings and seventy heathy controls were examined by using polymerase chain-restriction fragment length polymorphisms （PCR-RFLP） for F Ⅴ Leiden and F Ⅱ G20210A mutations. Results The F Ⅴ Leiden and F Ⅱ G20210A mutations were not detected in 45 sporadic BCS patients and two pairs of familial BCS patients and 70 controls. Conclusion There is no F Ⅴ Leiden and F Ⅱ G20210A mutations in Chinese BCS patients. The pathogenesis of BCS is not correlated with FⅤ Leiden and F Ⅱ G20210A mutations.
出处
《中华普通外科杂志》
CSCD
北大核心
2006年第4期275-277,共3页
Chinese Journal of General Surgery
