摘要
目的：探究慢性化脓性中耳炎患者脓液菌种分布情况，作药敏性分析，为临床合理应用抗生素提供指导。方法选择河南省人民医院2012年12月至2014年12月收治的150例慢性化脓性中耳炎患者作为研究对象，取患者中耳炎鼓室内脓液作细菌培养与药敏试验并记录结果，明确慢性化脓性中耳炎脓液菌种分布与耐药率。结果150例慢性化脓性中耳炎患者脓液标本共检出病原菌172株，其中真菌22株（12.79％），厌氧菌32株（18.60％），需氧菌118株（68.60％）；革兰阴性菌铜绿假单胞菌对亚胺培南、美罗培南、阿米卡星及哌拉西林药物敏感率为100.00％，奇异变形菌对头孢呋辛钠、头孢呋辛酯、头孢西丁、头孢噻肟、头孢吡肟、庆大霉素、头孢他啶、阿米卡星、亚胺培南、美罗培南、哌拉西林敏感率为100.00％；革兰阳性菌金黄色葡萄球菌对抗生素万古霉素、利奈唑烷、呋喃妥因敏感率为100.00％；凝固酶阴性葡萄球菌对抗生素万古霉素、利奈唑烷、呋喃妥因敏感率高。结论慢性化脓性中耳炎患者脓液中菌种分布提示以金黄色葡萄球菌与铜绿假单胞菌为主，在治疗方面，需严格参照细菌培养与药敏试验结果，选择敏感率高的抗生素，以提高临床治疗的有效性。
Objective To investigate the species distribution of chronic suppurative otitis media patients,analyze the drug sensitivity,and provide guidance for clinical rational use of antimicrobial drugs. Methods The 150 cases of chronic suppurative otitis media patients in Henan provincial people’s hospital from December 2012 to December 2014 year were treated as the research objects,cultured bacterial taken from tympanitis drum indoor pus of patients and made drug sensitivity test,recorded the results of drug sensitivity test and bacterial culture,cleared bacterial distribution in chronic suppurative otitis media pus and drug resistance rate. Results In this group,150 cases of chronic suppurative otitis media patients with inflammatory fluid specimens pus inspected 172 bacterial strains,including 22 strains of fungus（12. 79% ）, 32 strains of anaerobic bacteria（18. 60% ）,118（68. 60% ）strains of aerobic bacteria;the drug sensitivity rate of gram negative bacteria Pseudomonas aeruginosa to imipenem,meropenem,Amikacin and piperacillin were 100% ,sensitive rate of proteus bacteria to cefuroxime sodium,cefuroxime axetil,cefoxitin,cefotaxime,cefepime,ceftazidime,gentamicin, Amikacin,imipenem,meropenem,piperacillin were 100% ;sensitivity rate of gram positive bacteria Staphylococcus aureus to antibiotics vancomycin,linezolid,nitrofurantoin were 100% ;sensitivity rate of coagulase negative Staphylococcus to an-tibiotics vancomycin,linezolid,nitrofurantoin were high. Conclusions Prompt species distribution of patients with chronic suppurative otitis pus suggests bacterial is mainly composed of Staphylococcus aureus and Pseudomonas aeruginosa,strictly according to results of bacterial culture and drug sensitivity test,choose antimicrobial agents whose sensitive rate is high,to improve the clinical therapeutic effect.
出处
《中国实用医刊》
2016年第4期46-48,共3页
Chinese Journal of Practical Medicine
关键词
慢性化脓性中耳炎
脓液
药敏性
病原菌
Chronic suppurative otitis media
Fester
Drug sensitivity
Pathogenic bacteria
