摘要
目的研究扁平苔藓(Lichen Plsnus,LP)患者皮损处肿瘤坏死因子-α(TNF-α)和白介素-6(IL-6)的表达及其在LP发病过程中的作用。方法选取我院2012年8月至2013年10月收治的42例LP患者及39例皮肤正常患者,取LP患者的皮损组织和皮肤正常患者的皮肤组织,应用免疫组织化学技术检测两组皮肤组织中TNF-α和IL-6的表达水平,并对2指标进行相关性分析。结果 TNF-α及IL-6的阳性表达主要定位于表皮角质形成细胞和真皮浅层淋巴细胞的胞浆中;在正常皮肤组织的相同区域呈阴性或弱阳性表达。TNF-α和IL-6在LP皮损组织中的表达均高于在正常皮肤中的表达,差异有统计学意义(t=14.363,17.843;P<0.01),且二者在LP皮损处的表达水平呈正相关(r=12.116,P<0.01)。结论 TNF-α和IL-6可能在LP炎症反应的发生和发展中起重要作用,这对LP发病机制的研究及治疗方案的制定有重要意义。
Objective To study the expression of TNF - α and IL - 6 in patients with lichen planus and the pathogenesis of lichen planus. Methods Tissue samples were selected from the lesions of 42 patients with LP and normal skin of 39 patients adopting treat- ment in our hospital from Aug. 2012 to Oct. 2013. The expression of TNF - α and IL - 6 were detected with immune histochemical method. Results The positive expression of TNF - α and IL - 6 was mainly localized in the cytoplasm of keratinocytes and dermal lay- er of skin, in contrast with the negative or weakly positive expression in the normal skin tissue. The expression of TNF -α and IL - 6 in the LP tissue were higher than those in the normal skin tissue, with statistically significant difference （ t = 14. 363, 17. 843, P 〈 0. 01 ）, and the expression of TNF-α and IL- 6 in the LP tissue was positively correlated （r = 12. 116, P 〈0. 01 ）. Conclusion TNF - α and IL - 6 may fulfill an important role in the pathogenesis of LP, which is of great significance for the study of the pathogene- sis of LP and the formulation of treatment plan.
出处
《辽宁医学院学报》
CAS
2016年第1期63-65,F0003,共4页
Journal of Liaoning Medical University (LNMU) Bimonthly
