摘要
目的 探讨口服超声助显剂超声检查（oral ultrasonic contrast agent ultrasonography,OUCAUS）联合血清单核细胞趋化蛋白1（monocyte chemoattractant protein-1,MCP-1）和细胞黏附分子1（cell adhesion molecule-1,CAM-1）检测对胃癌术前分期的临床价值.方法 对新乡医学院第一附属医院800例胃癌患者术前行胃镜和OUCAUS检查并进行术前分期,同时用ELISA法检测其术前血清MCP-1和CAM-1水平,并与术后病理分期比较.结果 OUCAUS对胃癌侵犯深度、淋巴结转移和远处转移判断的总准确率分别为79.9％、82.9％和88.6％,血清MCP-1和CAM-1表达水平与胃癌组织浸润程度、淋巴结转移、远处转移和病理分期关系密切（均P ＜0.05）,OUCAUS联合血清MCP-1和CAM-1对胃癌侵犯深度、淋巴结转移和远处转移判断的总准确率分别为93.0％、93.9％和98.6％,对胃癌侵犯深度、淋巴结转移和远处转移判断的准确率明显高于仅依赖OUCAUS分期的准确率.结论 胃癌的病理分期与血清MCP-1和CAM-1表达密切相关,OUCAUS联合术前检测血清MCP-1和CAM-1水平有利于提高对胃癌浸润及转移判断的准确性.
Objective To explore the clinical value of oral ultrasonic contrast agent ultrasonography （OUCAUS） combined with serum monocyte chemoattractant protein-1 （MCP-1） and cell adhesion molecule-1 （CAM-1） measurement in preoperative staging of stomach carcinoma.Methods 800 gastric cancer patients were diagnosed by electric gastroscopy and OUCAUS.The preoperative staging was measured by OUCAUS and compared with pathologic staging,and serum levels of MCP-1 and CAM-1 were measured with ELISA.Results The total accuracy rate of OUCAUS was 79.9% in estimating invasive depth of stomach neoplasm,82.9% in estimating lymphatic metastasis and 88.6% in estimating distant metastasis respectively.The expression levels of MCP-1 and CAM-1 in serum were closely correlated with invasive degree,lymphatic metastasis,distant metastasis and pathologic staging （all P 〈 0.05）.The total accuracy rate of combining OUCAUS and MCP-1,CAM-1 was 93.0 % in estimating invasive depth,93.9% in estimating lymphatic metastasis and 98.6% in estimating distant metastasis respectively.The total accuracy rate of combining OUCAUS and MCP-1,CAM-1 in estimating invasive depth,lymphatic metastasis and distant metastasis was significantly higher than that of by OUCAUS alone.Conclusions MCP-1 and CAM-1 serum levels are closely correlated to pathologic staging of gastric cancer.Combining OUCAUS and MCP-1,CAM-1 can increase the accuracy rate determining invasion and metastasis in gastric cancer.
出处
《中华普通外科杂志》
CSCD
北大核心
2016年第3期208-211,共4页
Chinese Journal of General Surgery
基金
河南省教育厅科研基金资助项目（2011A320015）
