摘要
目的:探讨mNGF(鼠神经生长因子)对重症脑出血患者的疗效及对炎症因子、氧化应激的影响。方法:将84例于新疆自治区人民医院进行治疗的重症脑出血患者随机分为对照组和观察组,各42例。两组均给予控制颅内压、血糖等常规治疗,观察组在对照组的基础上加用mNGF。观察两组疗效,测定两组治疗前、后炎症因子超敏C反应蛋白(hs-CRP)、白介素8(IL-8)、肿瘤坏死因子(TNF-α)水平及氧化应激指标丙二醛(MDA)、超氧化物歧化酶(SOD)水平变化。结果:观察组的治疗总有效率显著高于对照组(P<0.05);与治疗前相比,两组患者hs-CRP、IL-8、TNF-α水平均显著降低(P<0.05),且观察组降低更显著(P<0.05);与治疗前相比,两组患者MDA、SOD水平显著降低(P<0.05),且观察组降低更显著(P<0.05)。结论:mNGF对重症脑出血患者疗效显著,可显著改善炎症反应和氧化应激反应。
Objective：To investigate the effect of mouse nerve growth factor（mNGF）on inflammatory factors and oxidative stress in patients with severe intracerebral hemorrhage.Methods：A total of 84 severe intracerebral hemorrhage patients were randomly divided into observation group（42cases）and control group（42cases）.The two groups were given the conventional therapy of controlling intracranial pressure and glucose,and the observation group was additionally given mNGF.To observe the efficacy of two groups,levels of hs-CRP,IL-8,TNF-αmalondialdehyde（MDA）and superoxide dismutase（SOD）were tested and compared in patients with severe intracerebral hemorrhage.Results：Total effective rate was significantly increased after treatment in observation group（P〈0.05）;hs-CRP,IL-8and TNF-αwere significantly reduced after treatment in two groups（P〈0.05）,and more significantly decreased in observation group（P〈0.05）;MDA and SO were significantly reduced after treatment in two groups（P〈0.05）,and more significantly decreased in observation group（P〈0.05）.Conclusion：The mNGF treatment has reliable curative effect in severe intracerebral hemorrhage patients,which can regulate inflammatory factors and oxidative stress.
出处
《海南医学院学报》
CAS
2016年第9期889-891,共3页
Journal of Hainan Medical University
基金
新疆维吾尔自治区科技厅支疆项目(201513441)~~
关键词
重症脑出血
mNGF
炎症因子
氧化应激
mNGF
Severe intracerebral hemorrhage
Inflammatory factors
Oxidative stress
