摘要
目的探讨肾病综合征出血热(HFRS)早期血清酶的变化特点及临床意义。方法回顾性分析2009年4月至2014年9月我院60例HFRS患者的临床资料,对其丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、α-羟丁酸脱氢酶(α-HBD)、乳酸脱氢酶(LDH)、碱性磷酸酶(AKP)、肌酸激酶(CK)、γ-谷氨酰转肽酶(γ-GT)的检测结果进行观察分析。结果 60例(100%)HFRS患者LDH、α-HBD水平均高于正常范围,54例(90%)患者AST水平高于正常范围,43例(71.67%)患者ALT水平高于正常范围,32例(53.33%)患者CK水平高于正常范围,而仅有18例(30%)患者AKP水平、11例(18.33%)患者γ-GT水平高于正常范围,多数患者正常。结论在HFRS患者早期血清酶诊断结果中,要格外关注ALT、AST、LDH及CK这四种酶的变化,对肾功能衰竭及多脏器功能损伤的防治具有很高的临床价值。
Objective To discuss the characteristics of changes and clinical significance of serum enzyme in the early stage hemorrhagic fever with renal syndrome（HFRS）. Methods Clinical data of 60 cases of HFRS patients from April 2009 to September 2014 were retrospectively analyzed, their test results of alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, α- hydroxybutyrate dehydrogenase（α-HBD）, lactate dehydrogenase（LDH）, alkaline phosphatase（AKP）, creatine kinase（CK）, r-glutamyl peptidase（γ-GT） were observed and analyzed. Results 60 cases（100%） of HFRS patients＇ LDH and α-HBD levels were above the normal range, 54 cases＇（90%） AST levels were above the normal range, 43 cases＇（71.67%） ALT levels were above the normal range, 32 cases,（53.33%） had CK levels above the normal range, while only 18 cases＇（30%） AKP levels and 11 cases＇（18.33%） γ-GT levels were above the normal range; the majority of patients were normal. Conclusion In the serum enzyme results of early HFRS patients, and to pay special attention to changes in ALT, AST, LDH and CK, which has high clinical value for prevention of renal failure and multiple organ damage.
出处
《中国医药指南》
2016年第5期115-116,共2页
Guide of China Medicine
关键词
肾病综合征出血热
血清酶
变化特点
临床意义
Hemorrhagic fever with renal syndrome
Serum enzyme
Changing characteristics
Clinical significance
