摘要
目的 :检测Rab27b在结直肠癌中的表达情况,并探讨Rab27b表达与结直肠癌中重要临床指标尤其是临床预后之间的关系。方法:在组织芯片上(80例肠癌标本及20例癌旁对照标本)进行免疫组化检测,使用Cox回归法及Kaplan-Meier生存分析法进行结直肠癌患者的预后分析。结果:免疫组化结果显示结直肠癌中的Rab27b表达明显高于癌旁对照组Rab27b的表达(P=0.041)。Rab27b的表达与结直肠癌患者的性别(P=0.012)、血清CEA水平(P=0.014)、远处转移(P=0.021)及TNM分期(P=0.013)有重要关联。生存分析显示Rab27b表达(P=0.021)与结直肠癌患者预后关系密切,Rab27b高表达提示预后不良。结论:Rab27b在结直肠癌组织中异常高表达,且Rab27b的表达与结直肠癌的数种恶性表型相关。Rab27b可作为结直肠癌患者预后的独立危险因素。
Objective： To detect the expression of Rab27 b in human colorectal cancer（CRC） and investigate the relationship between Rab27 b expression and clinical characteristics, especially the prognosis of CRC. Methods： Immunohistochemistry analysis by tissue microarrays（80 CRC samples and 20 tumor-adjacent tissue samples） was performed to characterize Rab27 b expression in CRC. Cox regression and Kaplan-Meier survival analyses were carried out to evaluate the prognosis of CRC. Results： Immunohistochemistry analysis showed that the expression of Rab27 b in CRC was significantly higher than that in normal tumor-adjacent tissues（P = 0.041）.Moreover, the expression level of Rab27 b protein in CRC was significantly related to gender（P = 0.012）, serum CEA level（P = 0.014）,distant metastasis（P = 0.021） and TNM stage（P = 0.013）. COX multi-factor analysis showed that Rab27 b expression（P = 0.021） could be recognized as an independent prognosis factor for CRC. Conclusion： Rab27 b expression was abnormally highly expressed and correlated with malignant phenotypes of CRC. It may serve as a novel prognostic factor for CRC.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2015年第10期1405-1408,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
南京医科大学肿瘤中心招标课题(11ZLKF06)
