摘要
目的:观察晚期肺癌不同中医证型化疗后骨髓抑制的规律性。方法:对145例ⅢB或Ⅳ期初治肺癌患者进行辨证分型,并接受标准含铂双药方案化疗,观察化疗后白细胞和中性粒细胞、血红蛋白、血小板下降的最低值,比较不同证型患者出现骨髓抑制的比例和骨髓抑制的类型。结果:化疗后气虚痰湿证出现骨髓抑制比率为32.6%,阴虚热毒证为44%,气阴两虚证为43.6%,气血瘀滞证为57.1%。气虚痰湿证与阴虚热毒、气阴两虚两证差异显著,与气血瘀滞证比较有显著性差异。阴虚热毒证和气阴两虚证差异显著。阴虚热毒证、气阴两虚证和气血瘀滞证比较,差异均有统计学意义。骨髓抑制类型方面,气虚痰湿证和气血瘀滞证均以白细胞减少为主,而阴虚热毒证和气阴两虚证以血红蛋白下降为主,其中,气血瘀滞证出现血小板减少几率明显高于其他三个证型。结论:晚期肺癌证型与化疗后骨髓抑制存在一定相关性,气血瘀滞证化疗后骨髓抑制发生率最高,阴虚热毒证和气阴两虚证次之,气虚痰湿证发生率最低。
Objective：To observe the correlation of TCM symdrom and myelosuppression after chemotherapy in advanced NSCLC. Methods： A total of 145 naive patients with advanced NSCLC were accepeted TCM syndrome differen- tiation and the first line platinum-based chemotherapy. The four groups of different TCM syndrome were compared the rate and type of myelosuppression after chemotherapy. Results： The incidence of myelosuppression in group with phlegm- dampness due to deficiency of qi syndrome was 32.6 ~, significant difference between group with yin-deficiency and toxic- stasis syndrome （44~） and group with deficiency of both qi and yin syndrome （43.6~）, dramatic significant difference between group with qi stagnation and blood stasis syndrome （57.1%）. Leukopenia was primary in group with phlegm- dampness due to deficiency of qi syndrome and group with qi stagnation and blood stasis syndrome, while anemia was pri- mary in group with yin-defieiency and toxic-stasis syndrome and group with deficiency of both qi and yin syndrome. Con- clusion： The TCM symdrom was related to myelosuppression after chemotherapy in advanced NSCLC. Group with qi stagnation and blood stasis syndrome had more myelosuppression than other TCM syndrome groups.
出处
《陕西中医》
2015年第12期1584-1586,共3页
Shaanxi Journal of Traditional Chinese Medicine
关键词
肺肿瘤
化疗反应
证候
Lung neoplasms Chemotherapy side-effects Symptom complex
