摘要
目的比较应用血浆醛固酮/血浆肾素活性(PAC/PRA,ARR)及血浆醛固酮/血浆肾素浓度(PAC/PRC,AARR)进行原发性醛固酮增多症(PA)筛查的特异性和敏感性差异,评价测定血浆肾素浓度在PA筛查中的价值。方法对20例经确证实验证实的原发性醛固酮患者和32例经筛查诊断为原发性高血压的患者测定ARR与AARR。结果 AARR和ARR卧位的ROC曲线下面积分别为0.904和0.854,AARR和ARR立位的ROC曲线下面积分别为0.951和0.961。ARR卧位cutoff值在70.5时,诊断原醛的敏感性和特异性分别为80%和78%;ARR立位cutoff值在78时,诊断原醛的敏感性和特异性分别为80%和100%;AARR卧位cutoff值在80.65时,诊断原醛的敏感性和特异性分别为93.3%和75.6%;AARR立位cutoff值在44.65时,诊断原醛的敏感性和特异性分别为100%和87.8%。AARR立位与ARR立位的诊断价值基本相当,有较高准确性,而AARR卧位比ARR卧位诊断价值要高。结论应用AARR与ARR筛查PA的准确性相当,AARR方法较ARR更为简便。
Objective Plasma aldosterone / plasma renin activity （PAC/PRA, ARR） and plasma aldosterone / plasma renin concentration （PAC/PRC, AARR） were used to evaluate the speciifcity and sensitivity of PA （PA） screening.MethodsARR and AARR were measured in 20 patients with essential hypertension and 32 patients with essential hypertension conifrmed by confirmatory test.ResultsThe area under the ROC curve of AARR and ARR was 0.854 and 0.904, respectively, and the area under the AARR＆amp;nbsp;curve of ROC and ARR was 0.951 and 0.961 respectively. The sensitivity and speciifcity of ARR were 78% and 80% when cutoff value was 70.5, the sensitivity and specificity of ARR was 80% and 100% respectively. The sensitivity and specificity of AARR were 93.3% and 80.65, respectively. The sensitivity and speciifcity of AARR were 100% and 87.8% respectively. The diagnostic value of AARR and ARR was similar to that of, and it had a higher accuracy, and the value of AARR was higher than that of ARR. Conclusion The accuracy of AARR and ARR in PA screening is quite, and the AARR method is more simple than ARR.
出处
《中国继续医学教育》
2015年第30期40-42,共3页
China Continuing Medical Education
