摘要
目的观察职业性噪声接触对作业工人肾素-血管紧张素(Ang)-醛固酮系统(RAAS)的影响。方法采用方便抽样法,选择45名疑似职业性噪声聋的工人为噪声接触组,根据其耳鸣症状、噪声接触强度和工龄分为无耳鸣亚组与耳鸣亚组、<90 dB亚组与≥90 dB亚组、工龄<10年亚组与工龄≥10年亚组;另选择45名无职业性噪声接触史工人为对照组。分别检测2组人群血压和血浆肾素活性(PRA)、AngⅠ、AngⅡ、醛固酮水平,计算醛固酮与PRA比值。结果噪声接触组人群舒张压高于对照组[(80±7)vs(76±8)mmHg,P<0.05];但2组人群收缩压比较,差异无统计学意义(P>0.05)。噪声接触组人群血浆AngⅡ水平高于对照组(中位数:100.98 vs 65.43μg/L,P<0.05);其余指标在2组人群间比较,差异均无统计学意义(P值均>0.05)。噪声接触组<90 dB亚组人群血浆AngⅡ水平高于对照组(中位数:123.16 vs 65.43μg/L,P<0.05);其余指标在噪声接触组2个耳鸣症状亚组、2个工龄亚组与对照组3组间分别比较,差异均无统计学意义(P值均>0.05)。噪声接触组与对照组人群血浆PRA、AngⅡ和醛固酮的异常率分别比较,差异均无统计学意义(P值均>0.05)。结论职业性噪声接触可能对RAAS造成影响,导致工人血浆AngⅡ水平升高。耳鸣和工龄可能不影响职业性噪声作业人群的RAAS。
Objective To observe the effects of renin-angiotensin(Ang)-aldosterone system(RAAS)in workers exposed to occupational noise.Methods Forty-five workers with suspected occupational noise-induced deafness were selected as noise exposure group using convenient sampling method.According to their tinnitus symptom,noise exposure intensity and work age,they were divided into no-tinnitus and tinnitus subgroups,<90 dB and≥90 dB subgroups,work years<10 years and≥10 years subgroups.Another 45 workers with no occupational noise exposure history were selected as control group.The levels of plasma renin activity(PRA),AngⅠ,AngⅡand aldosterone of the two groups were detected,and the aldosterone to renin activity ratio was calculated.Results The diastolic blood pressure of the noise exposure group was higher than that of the control group[(80±7)vs(76±8)mmHg,P<0.05].However,there was no significant difference in systolic blood pressure between the two groups(P>0.05).The level of plasma AngⅡin the noise exposure group was higher than that in the control group(median:100.98 vs 65.43μg/L,P<0.05).There was no statistical significance in other indexes between the two groups(all P>0.05).The plasma AngⅡlevel in<90 dB subgroup in the noise exposure group was higher than that of the control group(median:123.16 vs 65.43μg/L,P<0.05).There was no statistical significance in other indexes among the two subgroups of tinnitus symptom or work age in the noise exposure group and the control group(all P>0.05).There were no significant differences in the abnormal rates of PRA,AngⅡand aldosterone in plasma between the noise exposure group and the control group(all P>0.05).Conclusion Occupational noise exposure may affect RAAS and lead to increased plasma AngⅡlevels in the workers.Tinnitus and work age may not affect RAAS in occupational noise-exposure workers.
作者
吴奇峰
李绮萍
李聪
梁伟辉
李斌
李婉莉
邓小峰
WU Qi-feng;LI Qi-ping;LI Cong;LIANG Wei-hui;LI Bin;LI Wan-li;DENG Xiao-feng(Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment,Guangzhou,Guangdong 510300,China)
出处
《中国职业医学》
CAS
北大核心
2022年第6期640-644,共5页
China Occupational Medicine
基金
国家临床重点专科建设项目(2011-09)
广东省职业病防治重点实验室(2017B030314152)
广东省医学科学技术研究基金(B2015070)
关键词
噪声
职业接触
血管紧张素
肾素
醛固酮
耳鸣
工龄
Noise
Occupational exposure
Angiotensin
Renin
Aldosterone
Tinnitus
Seniority
